🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-tyrosine and velvet bean seed extract are used to support dopamine precursor levels, while vitamin B6, Metafolin, and zinc act as enzymatic cofactors in neurotransmitter synthesis. Research providing evidence for these specific combinations is limited. The ingredient profile maintains a high safety rating.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Label Data

3 Capsule(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

6.7 mg (394% DV)
📊 5.2× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 6.7mg UL 100mg
Metafolin
833 mcg DFE (208% DV)
10 mg (91% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 263 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
1000 mg
📊 Market median: 500.0mg (223 products) 📚 24 studies (Tier A: 0, B: 1)
This product: 1000mg
Velvet Bean Seed Extract
200 mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 100mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 100mg
📊 Market median: 260.0mg (249 products) 📚 158 studies (Tier A: 4, B: 61)
This product: 100mg

Other Ingredients

Cellulose Water

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 3 capsules, 1-2 times daily, with low protein foods.

Take with food.

⚠️ Warnings & Precautions

Warning: Not to be taken by pregnant or lactating women. If you have liver problems, any other health condition or are taking any medication, particularly psychiatric medication, consult your health professional before use. Do not use concurrently with antidepressants, antipsychotics, or drugs used to treat Parkinson's disease.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

GFCO.org (Gluten-Free Certification Organization) Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

PureSYNAPSE product line; Supports cognition and behavioral health Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 66298 01455 5
DSLD Entry Date 2024-06-20
Product Type Botanical with Nutrients
Form Capsule
DSLD ID 309484
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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DSLD ID: 309484 Fetched: 2026-04-11
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