Home/ Supplements/ Folate/ TMG 175 mg with Folinic Acid & Methyl B1...

TMG 175 mg with Folinic Acid & Methyl B12

product on market Capsule Kirkman Safety: 87/100
87/100

This product is generally safe

  • Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Trimethylglycine, folate, and methyl B12 support methylation processes and homocysteine regulation. Research provides moderate to strong evidence for these nutrients in maintaining cellular function and neurological health. The formulation maintains a high safety profile for general supplementation.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for TMG 175 mg with Folinic Acid & Methyl B12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
200
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

333 mcg DFE (83% DV)
Exceeds UL by 333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
6 mcg (250% DV)
2.5× RDA — within safe limits 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hypromellose Water Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested Use: Take one to four capsules daily or as directed by a physician.

Warnings & Precautions

Keep out of the reach of children.

Formulation Notes

Free of: Milk, Eggs, Fish, Shellfish, Tree Nuts, Peanuts, Wheat or Soy

Hypoallergenic

Gluten-Free

Additional Information

Important: Store in a cool dry place and tightly capped.

Ultra Tested cGMP certified

503.694.1600

Metadata

Product Details

UPC / SKU8 12325 02101 7
DSLD Entry Date2023-10-24
Product TypeOther Combinations
FormCapsule
BrandKirkman
DSLD ID297261
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Bio-Plus Biotin With Folic Acid
Douglas Laboratories · Capsule
100
Folic Acid
OL Olympian Labs · Capsule
100
L-5-MTHF Natural S-Isomer
Designs for Health · Capsule
100
Folic Acid
DaVinci Laboratories Of Vermont · Capsule
100
SAMe with Vitamins B-6, B-12 and 5-MTHF
Designs for Health · Capsule
100
View all Folate products →
Folate research Best Folate All Folate products More from Kirkman View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.