CoQ10-Plus by Irwin Naturals — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
35% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

2 Liquid Softgel(s) Serving Size

30 Servings

Other Combinations Product Type

35% Evidence Coverage

Supplement Facts — Evidence Check

Calories

15 Calorie(s)

Total Fat

1 Gram(s) (1% DV)

Cholesterol

5 mg (2% DV)

Total Carbohydrates

1 Gram(s) (1% DV)

Protein

1 Gram(s)

Vitamin D3

25 mcg (125% DV)

✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.025mg UL 0.1mg

Fish Oil

700 mg

📊 Market median: 750.0mg (447 products) 📚 388 studies (Tier A: 18, B: 204)

This product: 700mg UL 3000mg

Hawthorn Berry Extract

200 mg

📊 Market median: 333.0mg (166 products) 📚 9 studies (Tier A: 0, B: 2)

This product: 200mg

Ginkgo Leaf Extract

120 mg

📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)

This product: 120mg

Chia Seed Oil

100 mg

Coenzyme Q-10

100 mg

📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)

This product: 100mg UL 1200mg

Cayenne, Powder

60 mg

Gotu Kola Whole Herb Extract

60 mg

Citrus (Citrus spp.) fruit extract

50 mg

Hibiscus Flower Extract

50 mg

Resveratrol

10 mg

📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)

This product: 10mg

BioPerine Complex

6 mg

Other Ingredients

Gelatin Water, Purified Glycerin Beeswax Annatto Soy Lecithin Dextrin Silicon Dioxide Maltodextrin Titanium Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (87% of products) Nutrient (13% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

This product can be taken daily for ongoing heart maintenance.

Directions: (Adult) Take two (2) Liquid Soft-Gels daily with a meal and a full glass (8 oz) of water.

⚠️ Warnings & Precautions

Usage warnings: Do not use if safety seal is broken.

This product contains an ingredient that may affect blood sugar.

Check with your doctor before using this product if you are using medication, including anticoagulant and heart medications, or have any medical conditions, including heart disease and/or high blood pressure. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: fish (anchovy, sardine), soy

🧪 Formulation Notes

Coenzyme Q10 (CoQ10) is a substance that can be naturally produced by the body. It is used by the cells, including heart and blood cells, to generate energy and as a powerful antioxidant to combat free radicals and oxidative stress. As we age, CoQ10 levels may decrease, so that is why we formulated CoQ10-Plus Optimum Heart Health, a multi-prolonged formula for optimum heart health. This unique formula utilizes patented BioPerine for enhanced absorption. CoQ10-Plus Optimum Heart Health also features a wide range of targeted ingredients that support overall heart health including CoQ10 and Vitamin D3. Also included are Fish Oil and Chia Seed Oil that supply Omega 3s.This product also supplies a broad spectrum of botanicals such as Hawthorne Berry, Ginkgo, Cayenne, and Gotu Kola, that are often found in traditionally used formulas to support cardiovascular health. This unique formula utilizes patented BioPerine for enhanced absorption.

What makes us different: Liquid soft-gels - the nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced liquid soft-gels provide an optimum delivery system.

Patented BioPerine - our special BioPerine complex enhances the bioavailability, absorption and potency of many nutrients.

Plus chia seed oil

Optimum heart health

BioPerine enhanced absorption. Plus vitamin D3, ginkgo biloba, resveratrol and fish oil

No preservatives added.

Additional Information

Pass Quality Tested Guaranteed

Quality assurance - Irwin naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency. Global responsibility - over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Questions: contact consumer affairs Weekdays 8:00 AM to 5:00 PM (PST) 100+ highly specialized products:

Full disclosure ingredient panel

Product Details

UPC / SKU 7 10363 58578 5

DSLD Entry Date 2023-10-24

Product Type Other Combinations

Form Softgel Capsule

Brand Irwin Naturals

DSLD ID 292126

Data Updated 2026-04-11

Research Evidence

202 Research Sources

55 Avg Quality Score

86 Meta Analysis

62 Systematic Review

28 Rct

17 Clinical Trial

4 Regulatory Source

2 Other

1 Narrative Review

1 Openfda Safety

A Coenzyme Q10 for heart failure

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI Cochrane

A Cardioprotective interventions for cancer patients receiving anthracyclines

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI

A Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis

Meta Analysis BMJ open 2021

PubMed DOI

A Effects of coenzyme Q10 supplementation on statin-induced myopathy: a meta-analysis of randomized controlled trials

Meta Analysis Irish journal of medical science 2022

PubMed DOI

B Cardioprotective interventions for cancer patients receiving anthracyclines

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI

B Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

B Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

Meta Analysis Reproductive sciences (Thousand Oaks, Calif.) 2023

PubMed DOI

B Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials

Meta Analysis International journal of molecular sciences 2020

PubMed DOI

B Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis

Meta Analysis Journal of nutritional science 2025

PubMed DOI

B Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension

Meta Analysis The Cochrane database of systematic reviews 2009

PubMed DOI Cochrane

View all evidence for Coq10 →