🟢 95/100

This product looks safe

  • Folate: 500mg is 500.0× the Tolerable Upper Intake Level (1.0mg)
  • 71% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 500mg is 500.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Vegetarian Capsule(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
71% Evidence Coverage

Supplement Facts — Evidence Check

15 mg (1250% DV)
📊 12.5× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 15mg
25 mg (156% DV)
✅ 1.8× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 25mg UL 35mg
500 mcg DFE (125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 500.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 500mg UL 1.0mg
250 mcg (10417% DV)
📊 104.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.25mg
25 mg (500% DV)
📊 5.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 25mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 300mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Vegetable Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Suggested usage: Adults take 1 capsule daily or as directed by a health professional.

⚠️ Warnings & Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication (particularly antidepressants or other psychiatric medication, anticoagulants, oral contraceptives, anti-depressants, anti-seizure medications, drugs to treat HIV or prevent transplant rejection), consult your physician before using this product.

This product may cause skin rashes or photosensitivity in some people. Avoid excessive exposure to sunlight, tanning lights or UV sources while taking this product. This product may cause serotonin syndrome in sensitive patients and may cause hair loss.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Gluten-free, Non-GMO

Serotonin support

Additional Information

Store in a cool, dry place.

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Product Details

UPC / SKU 3 10539 01956 6
DSLD Entry Date 2023-06-22
Product Type Botanical with Nutrients
Form Capsule
DSLD ID 286487
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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