SAMe 200 mg + Cofactors
94/100
This product looks safe
- Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
- 83% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
83%
Evidence Coverage
Supplement Facts — Evidence Check
2 mg
(118% DV)
✅ 1.5× RDA — within safe limits
📚 113 studies (Tier A: 3, B: 35)
333 mcg DFE
(83% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 333.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
500 mcg
(20833% DV)
📊 208.3× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
Calcium
20 mg
(2% DV)
20 mg
(5% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
200 mg
📊 Market median: 200.0mg (52 products)
📚 10 studies (Tier A: 0, B: 6)
Other Ingredients
L-Leucine
Vegetarian Cellulose
Gellan Gum
Label Claims — Verification
❓
All Other
All Other (100% of products)
Structure/Function (83% of products)
Nutrient (6% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Dairy Free
Product Information
📋 Directions for Use
Best consumed within 90 days after opening.
Directions: One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.
⚠️ Warnings & Precautions
Caution: Pregnant or lactating women, consult your healthcare professional before taking this product.
If you suffer from bipolar (manic) depression, do not use this product.
Keep tightly closed in a cool, dry place, out of the reach of children.
🧪 Formulation Notes
Moisture sensitive formula.
Egg free Gluten free Free of nuts Dairy free
Manufactured in a GMP Compliant Facility
Additional Information
Keep tightly closed in a cool, dry place, out of the reach of children.
Product Details
UPC / SKU
8 38287 00156 0
DSLD Entry Date
2022-09-22
Product Type
Other Combinations
Form
Capsule
Brand
Metabolic Maintenance
DSLD ID
274194
Data Updated
2026-04-11
Research Evidence
12
Research Sources
58
Avg Quality Score
8
Meta Analysis
3
Systematic Review
1
Rct
B
S-adenosyl-L-methionine for alcoholic liver diseases
B
S-adenosyl methionine (SAMe) for depression in adults
B
Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
B
SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
B
S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
B
S-adenosyl-L-methionine for alcoholic liver diseases
C
S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
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