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SAMe 200 mg + Cofactors

product on market Capsule Metabolic Maintenance Safety: 94/100
94/100

This product looks safe

  • Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
  • 83% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The formula combines B vitamins and minerals that support neurological function and metabolic processes. Research provides strong evidence for the roles of B6, B12, and folate in homocysteine regulation and cognitive health. Calcium and magnesium are well-documented for their contributions to neuromuscular stability and bone maintenance.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for SAMe 200 mg + Cofactors
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
83%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
333 mcg DFE (83% DV)
Exceeds UL by 333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
20 mg (2% DV)
20 mg (5% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

L-Leucine Vegetarian Cellulose Gellan Gum
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Best consumed within 90 days after opening.

Directions: One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.

Warnings & Precautions

Caution: Pregnant or lactating women, consult your healthcare professional before taking this product.

If you suffer from bipolar (manic) depression, do not use this product.

Keep tightly closed in a cool, dry place, out of the reach of children.

Formulation Notes

Moisture sensitive formula.

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Metadata

Product Details

UPC / SKU8 38287 00156 0
DSLD Entry Date2022-09-22
Product TypeOther Combinations
FormCapsule
BrandMetabolic Maintenance
DSLD ID274194
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.