🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 400mg

Other Ingredients

Hypromellose Rice Flour Magnesium Stearate Gellan Gum

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Suggested use: For adults, take one (1) capsule once or twice daily before a meal, or as directed by your physician. Do not take more than two (2) servings per day.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose.

Not intended for pregnant or nursing mothers.

Not intended for children under 18 years of age.

If you are taking medications (especially antidepressants), have a known medical condition, or are planning to have a medical condition, or are planning to have a medical procedure, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Individuals with bipolar disorder and manic depression should avoid this supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

🧪 Formulation Notes

Maximum strength Enhances well-being and positive mood Increases brain function Support joint & liver health

Additional Information

Store in a cool, dry place.

Formulated in the U.S.A.

Please recycle.

Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured

Product Details

DSLD Entry Date 2022-02-23
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 260819
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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