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SAMe (S,S Isomer) 1100 mg

product on market Capsule NusaPure Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is researched for its potential to support mood and joint health. There is moderate evidence suggesting its efficacy in managing depressive symptoms and osteoarthritis. Clinical data supports a high safety profile for most users when taken as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe (S,S Isomer) 1100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

4 Veg Capsule(s)
Serving Size
37
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1100 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Silica Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take four (4) capsules daily between meals or as recommended by a health professional.

Warnings & Precautions

Warning: For adults only.

Individuals using antidepressants medications should consult with their prescribing physician prior to using this product.

Individuals diagnosed with bipolar disease or manic depression should avoid this product.

Do not use if pregnant or nursing.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

SAMe (S,S Isomer) 1100 mg per serving

Assembled in USA Tested Supports well-being & healthy mood Promotes healthy brain function Supports joint & liver health

Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, or tree nut ingredients.

Natural color variation may occur in this product.

Additional Information

Store in a cool, dry place after opening.

Please recycle.

Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

Metadata

Product Details

UPC / SKUX002982N39
DSLD Entry Date2021-04-22
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID246946
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.