🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 18% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Label Data

48.64 Gram(s) Serving Size
30 Servings
Other Combinations Product Type
18% Evidence Coverage

Supplement Facts — Evidence Check

Calories
130 {Calories}
Total Carbohydrates
33 Gram(s) (11% DV)
Sodium
30 mg (1% DV)
5250 mg
📊 Market median: 5.0mg (298 products) 📚 701 studies (Tier A: 5, B: 123)
This product: 5250mg
2000 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 2000mg
1500 mg
📊 Market median: 500.0mg (143 products)
This product: 1500mg
500 mg
📊 Market median: 17.4mg (161 products)
Median 17.4mg This product: 500mg
500 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 500mg
250 mg
📊 Market median: 17.4mg (161 products)
Median 17.4mg This product: 250mg
L-Valine
250 mg
L-Phenylalanine
250 mg

Other Ingredients

Dextrose Citric Acid Polysorbate 80 Calcium SIlicate Sodium Citrate

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (93% of products) Nutrient (20% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS: As a dietary supplement, mix one scoop (48.64 g) in 6-8 oz of cold water or your favorite sports beverage. For best results on training days, take immediately post-workout. On non-training days, take first thing in the morning.

⚠️ Warnings & Precautions

Product manufactured in a facility that also processes the following allergens: Milk, Soy, Wheat, Egg and Peanut.

Phenylketonurics: Contains Phenylalanine.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Discontinue two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

5250MG CREATINE 130CALORIES 33G SUGAR 33G CARBS

Phenylketonurics: Contains Phenylalanine.

Additional Information

THE BENEFITS OF HYBRID CREATINE COMPLEX

With this formula you get superior results during and after your workout. Best of all, it mixes instantly with a spoon and tastes absolutely refreshing. Your muscles can only grow when your body retains enough nitrogen. Some of the most effective sources of nitrogen for fueling lean muscle are creatine and amino acids. The specially manufactured Hybrid Creatine Complex formula delivers an anabolic creatine and amino acid spike into your bloodstream when you need it most. This spike provides nitrogen and subsequently creates a nitrogen-rich environment needed for maximizing lean muscle mass.

This scientifically advanced complex has been clinically shown to dramatically increase bench press, vertical jump and 100 yard dash performance!^*

The full muscle building potential of a GNC product is based on its total nitrogen content - so the more nitrogen a product has, the stronger it will perform.

INFORMED-CHOICE{check}.ORG Trusted by sport

Products bearing this logo must have been tested for banned substances by HFL Sport Science, a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2012 World Anti-Doping Agency (WADA) Prohibitied List via HFL skip lot testing protocol #ICP0307. See gnc.com for more information.

^Eight weeks of supplementation with the creatine and carbohydrate blend in this formula in male collegiate athletes during off-season training produced significant increases in several performance variables compared to those athletes taking 34g carbohydrate formula alone.* Subjects taking the creatine and carbohydrate blend in this formula displayed increased performance in the bench press, vertical jump and 100 yard dash compared to those taking the carbohydrate formula alone.* +When used in conjunction with regular resistance training.

Creatine Formula Clinically Proven to Increase Strength & Performance ^* 5250mg of Powerful Creatine + Amino Acids to Help Build Muscle+* Hybrid Nutrient Formula to Support Superior Creatine Uptake*

BANNED SUBSTANCE FREE*

NITRO-FACTOR 16G(TM)

Daily Post-Workout Strength Power

CODE 370099 LNG

NOTICE: Significant product settling may occur.

{QR Code} SCAN & LEARN MORE

Store in a cool, dry place.

Product Details

UPC / SKU 0 48107 12468 7
DSLD Entry Date 2013-11-25
Product Type Other Combinations
Form Powder
DSLD ID 27358
Data Updated 2026-04-11

Research Evidence

739 Research Sources
47 Avg Quality Score
472 Clinical Trial
139 Meta Analysis
74 Systematic Review
47 Rct
2 Regulatory Source
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data
Meta Analysis JAMA psychiatry 2021
A HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
Meta Analysis The Cochrane database of systematic reviews 2014
A Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease
Meta Analysis The Cochrane database of systematic reviews 2014
B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024
B Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis
Systematic Review BMC medicine 2019
B Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2021
B The Effects of Creatine Supplementation on Upper- and Lower-Body Strength and Power: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2025
B Meta-analysis of the efficacy and safety of Finerenone in diabetic kidney disease
Meta Analysis Medicine 2026
B Creatine and creatine analogues in hypertension and cardiovascular disease
Meta Analysis The Cochrane database of systematic reviews 2011
B HMG CoA reductase inhibitors (statins) for dialysis patients
Meta Analysis The Cochrane database of systematic reviews 2013
View all evidence for Creatine →

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