🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Vcap(s) Serving Size
180 Servings
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

Advanced Enzyme Complex
225 mg
100 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 100mg
Ox Bile Extract
25 mg
Papaya fruit powder
50 mg
100 mg
📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews
This product: 100mg
📊 Market median: 60.0mg (107 products) 📚 1 studies — no high-quality reviews
This product: 50mg
Apple Pectin, Powder
50 mg
Black Pepper powder
5 mg

Other Ingredients

Magnesium Stearate Silicon Dioxide Vegetable Cellulose

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take one (1) capsule with each meal. Consider taking these other Best Naturals products: Probiotics and Aloe Vera softgels.

⚠️ Warnings & Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

🧪 Formulation Notes

Certain research publications indicate that it may help support the following. Supports healthy digestive function. Promotes healthy bowel movement. Promotes constipation relief.

Premium formula

Advanced enzyme complex

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no egg, no gluten, no wheat, no yeast, no fish. Sodium free.

Additional Information

Keep in cool, dry place.

Made in USA

GMP Good Manufacturing Practice Product

For additional information call 1-877-659-6004

Product Details

UPC / SKU 8 17716 01249 0
DSLD Entry Date 2022-07-21
Product Type Other Combinations
Form Capsule
DSLD ID 269598
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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