🟢 94/100

This product looks safe

  • Vitamin B3: 460mg is 13.1× the Tolerable Upper Intake Level (35mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Vitamin B3: 460mg is 13.1× the Tolerable Upper Intake Level (35mg)

Label Data

3 Vegetable Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

460 mg (2300% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 13.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 460mg UL 35mg
📊 Market median: 1000.0mg (223 products) 📚 11 studies (Tier A: 0, B: 5)
This product: 750mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 600mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 250mg
Seanol-P
15 mg
Bioperine
3 mg

Other Ingredients

Rice Flour Silica Hydroxypropylmethylcellulose Monostearin

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: Three vegetable capsules twice daily or 2 capsules three times daily with meals, or as directed by a health care professional.

⚠️ Warnings & Precautions

Do not use if you are pregnant, may become pregnant, or are breast feeding, because using this product may cause birth defects.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of reach of children.

Contains: soy.

🧪 Formulation Notes

Clinically formulated to support normal range blood lipid levels.

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Additional Information

Sold only for dispensing by a licensed health care professional.

Formulated by Mitchell A. Fleisher, M.D., D.Ht., D.A.B.F.M., Dc.A.B.C.T.

Certified GMP Compliant GMP Good Manufacturing Practice 21 CFR 111

Product Details

UPC / SKU 3 51821 01051 9
DSLD Entry Date 2022-04-11
Product Type Other Combinations
Form Capsule
DSLD ID 261242
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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