Home/ Supplements/ Folate/ TMG 500 mg W/Folinic Acid & Methyl B-12

TMG 500 mg W/Folinic Acid & Methyl B-12

product on market Capsule Kirkman Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Trimethylglycine, folinic acid, and methyl B-12 are researched for their roles in supporting methylation and homocysteine regulation. There is strong evidence for B-vitamin efficacy in metabolic function, though specific clinical data for this combined formulation is limited. These ingredients are generally recognized as safe for supplementation.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for TMG 500 mg W/Folinic Acid & Methyl B-12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
6 mcg (100% DV)
2.5× RDA — within safe limits 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Trimethylglycine Di-Calcium Phosphate Calcium Folinate Magnesium Stearate Methylcobalamin Plant Cellulose Capsule
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

SUGGESTED USE: 1-2 capsules daily or as directed by a physician.

Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

Formulation Notes

FREE OF: Sugar, starch, soy, wheat, casein, gluten, milk, corn, preservatives, yeast, gelatin, flavorings, colorings, peanuts, tree nuts or fish.

CASEIN & GLUTEN FREE

HYPOALLERGENIC

Additional Information

IMPORTANT: STORE IN A COOL DRY PLACE AND TIGHTLY CAPPED.

(503)694-1600

Best Used by: April 2013

309/120

Metadata

Product Details

DSLD Entry Date2013-09-25
Product TypeOther Combinations
FormCapsule
BrandKirkman
DSLD ID25795
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.