Home/ Supplements/ Niacin/ Optimized TryptoPure Plus

Optimized TryptoPure Plus

product on market Capsule Life Extension Safety: 80/100
80/100

This product is generally safe

  • Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 25% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-tryptophan and niacin are supported by moderate evidence for supporting mood and metabolic functions, while L-lysine is used for immune support. The proprietary botanical blend has limited clinical documentation. Overall, these ingredients are generally well-tolerated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Optimized TryptoPure Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

66 mg (330% DV)
Exceeds UL by 1.9× (UL: 35 mg) 196 studies (A:5, B:63)
Market median: 500.0mg (70 products)
250 mg
Market median: 500.0mg (159 products)
Proprietary TryptoPure Plus Blend (Herb/Botanical)
285 mg

Other Ingredients

Vegetable Cellulose Magnesium Stearate Maltodextrin Rice Flour modified Food Starch Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: Take 2-3 capsules all at once before bedtime, or one capsule on an empty stomach before each meal, or as recommended by a healthcare practitioner. For maximum absorption take with a small amount of carbohydrate, such as diluted juice.

Take separately from food or supplements containing protein or amino acids, especially arginine.

Warnings & Precautions

WARNINGS: - KEEP OUT OF REACH OF CHILDREN.

Contains corn and rice.

- DO NOT EXCEED RECOMMENDED DOSE.

- Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition.

CAUTION: Serotonin syndrome is characterized by high levels of serotonin and symptoms like confusion, sweating, agitation, nausea, involuntary muscle contractions, and racing heartbeat. Do not take L-tryptophan if you experience these symptoms. Do not take L-tryptophan in combination with other agents that increase serotonin levels in the central nervous system. Agents that increase serotonin levels can include psychiatric medications (e.g. antidepressants, lithium), migraine medications (e.g. sumatriptan), Parkinson’s disease medications (e.g. carbidopa), and dextromethorphan, an over-the-counter cough suppressant. Do not use before driving or operating heavy machinery.

Formulation Notes

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives

Additional Information

Store tightly closed in a cool, dry place.

01202A Rev. 10/08

Advanced L-Tryptophan Formula

Natural Sleep Enhancement and Stress Reduction*

Read the entire label and follow the directions carefully prior to use.

AJIPURE(TM) AMINO ACIDS

Metadata

Product Details

UPC / SKU7 37870 12029 2
DSLD Entry Date2011-11-25
Product TypeBotanical with Nutrients
FormCapsule
DSLD ID2511
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.