🟢 95/100

This product looks safe

  • Niacin: 45mg is 1.3× the Tolerable Upper Intake Level (35mg)
  • 75% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 45mg is 1.3× the Tolerable Upper Intake Level (35mg)

Label Data

1 Veg Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

45 mg (281% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 45mg UL 35mg
8 mg (471% DV)
📊 6.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 8mg UL 100mg
6.5 mg (2% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 6.5mg
GABA
200 mg
Glycine
200 mg
200 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 200mg
100 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 100mg
25 mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 25mg

Other Ingredients

Cellulose Magnesium Stearate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1 capsule 1 to 3 times daily, preferably on an empty stomach or just before meals.

⚠️ Warnings & Precautions

Caution: For adults only. May reduce the ability to drive or operate machinery.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

To report a serious adverse event, or for product information, contact 1-800-234-8686

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

This product is a combination of amino acids and their cofactor nutrients formulated to support the normal production and function of calming neurotransmitters in the brain. This product includes GABA and glycine, two amino acids that promote relaxed state of mind, along with Taurine, another amino acid with calming properties. These nutrients are blended with Valerian, which is known to interact with the GABA receptors in the nervous system.

Natural color variation may occur in this product.

Amino acid

Relaxing formula

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Non-GMO

Additional Information

Douglas Cooper Co. "Trace Minerals Make the Difference" Since 1950

Product Details

DSLD Entry Date 2021-05-22
Product Type Other Combinations
Form Capsule
DSLD ID 247396
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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