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5-HTP Complex

product on market Capsule Higher Nature Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

This profile contains B vitamins and zinc, which are moderately supported by research for supporting energy metabolism and cognitive function. However, the overall evidence coverage for this specific combination is very limited. These ingredients are generally recognized as safe for consumption within recommended daily limits.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
28
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

15 mg NE (94% DV)
1.1× RDA — within safe limits 196 studies (A:5, B:63)
5 mg (357% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
50 mcg (25% DV)
Within RDA (0.1× RDA) 226 studies (A:10, B:105)
25 mcg (50% DV)
Within RDA (0.8× RDA) 27 studies (A:0, B:11)
2.5 mg (25% DV)
Within RDA (0.2× RDA) 263 studies (A:6, B:134)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Rice Bran Capsule L-5-Hydroxytryptophan Nicotinamide Zinc Citrate Pyridoxal 5-Phosphate Pyridoxine Hydrochloride Silicon Dioxide Magnesium Stearate Folic Acid Biotin Ingredients
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 strip (containing 3 different capsules) daily 45 minutes before bed.

Warnings & Precautions

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

Warning: Consult your doctor if under medical supervision or taking prescribed medications. Not advisable if pregnant, breastfeeding or if taking antidepressants.

Can cause drowsiness; do not drive or operate machinery if affected.

Formulation Notes

Includes one each of High Strength Magnesium, L-Theanine and 5-HTP Complex. The perfect combination of nutrients to support a restful night and help you wake up feeling refreshed 5-HTP and l-theanine for targeted support Magnesium and vitamin B3 are vital for the normal functioning of the nervous system With zinc for normal cognitive function

A trio of supplements in a handy daily strip to help you have a relaxed and restful night

Vegetarian & vegan

Free from: Artificial colours, flavourings or preservatives, dairy products, gluten, lactose, salt, soya, sugar, wheat, yeast.

Additional Information

NRV = Nutrient Reference Value

Storage: Store in a cool, dry place out of reach of children.

Also try daily nutrients for... Calm Energy & vitality Immunity Vegans

Blister strips not to be sold separately

This product has not been tested on animals.

Metadata

Product Details

UPC / SKU5 031013 108761
DSLD Entry Date2021-04-22
Product TypeOther Combinations
FormCapsule
BrandHigher Nature
DSLD ID246114
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.