Serotone 5-HTP 50 mg

product on market Capsule Higher Nature 🟢 Safety: 100/100
Brand: Higher Nature
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
45 Servings
Botanical with Nutrients Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

15 mg NE (94% DV)
✅ 1.1× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 15mg UL 35mg
5 mg (357% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
50 mcg (25% DV)
✅ Within RDA (0.1× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.05mg UL 1.0mg
25 mcg (50% DV)
✅ Within RDA (0.8× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.025mg
2.5 mg (25% DV)
✅ Within RDA (0.2× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 2.5mg UL 40mg
50 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 50mg

Other Ingredients

Rice Bran Hydroxypropyl Methylcellulose L-5-Hydroxytryptophan Vitamin B3 Zinc Citrate Vitamin B6 Vitamin B6 Silicon Dioxide vegetarian Magnesium Stearate Folic Acid Biotin

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Take 1-2 capsules a day preferably before bed with a carbohydrate snack. Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

⚠️ Warnings & Precautions

Storage: Store in a cool,dry place out of reach of children.

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Warning: Consult your doctor if under medical supervision or taking prescribed medications. Not advisable if pregnant, breastfeeding or if taking antidepressants.

Can cause drowsiness; do not drive or operate machinery if affected.

🧪 Formulation Notes

Free from: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, sugar, wheat, yeast.

Vegetarian and vegan

Advanced formula Optimal benefit

5-HTP is an amino acid needed to produce serotonin Vitamins B3 and B6 contribute to normal psychological function

Additional Information

NRV = Nutrient Reference Value

Storage: Store in a cool, dry place out of reach of children.

Mind Health

This product has not been tested on animals.

Product Details

UPC / SKU 5 031013 100109
DSLD Entry Date 2021-04-22
Product Type Botanical with Nutrients
Form Capsule
Brand Higher Nature
DSLD ID 245816
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
PubMed Cochrane
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
PubMed Cochrane
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
PubMed DOI
View all evidence for 5 Htp →

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