Homocysteine Resist by Life Extension — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 8500mg is 8500.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Vegetarian Capsule(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

25 mg (1923% DV)

📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 25mg

Vitamin B6

100 mg (5882% DV)

📊 76.9× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 100mg UL 100mg

Folate

8500 mcg DFE (2125% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 8500.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 8500mg UL 1.0mg

Vitamin B12

1000 mcg (41667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Other Ingredients

Microcrystalline Cellulose Vegetable Cellulose Stearic Acid Silica Rice Extract Blend

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.

1 Daily

⚠️ Warnings & Precautions

Caution: Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your healthcare provider.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

🧪 Formulation Notes

Gluten free Non GMO LE Certified

Maintains healthy arteries

Additional Information

Non GMO LE Certified

Store tightly closed in a cool, dry place.

Product Details

UPC / SKU 7 37870 21216 4

DSLD Entry Date 2020-08-23

Product Type Vitamin

Form Capsule

Brand Life Extension

DSLD ID 232326

Data Updated 2026-04-11

Research Evidence

22 Research Sources

49 Avg Quality Score

8 Rct

4 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Cochrane Review

1 Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024

PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022

PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010

PubMed DOI Cochrane

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews

PubMed DOI Cochrane

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017

PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010

PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023

PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014

PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015

PubMed DOI

View all evidence for Riboflavin →