🟢 85/100

This product is generally safe

  • Niacin: 80mg is 2.3× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 75% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 80mg is 2.3× the Tolerable Upper Intake Level (35mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Capsule(s) Serving Size
Other Combinations Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

80 mg (4700% DV)
📊 61.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 80mg
80 mg (400% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 80mg UL 35mg
80 mg (4000% DV)
📊 61.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 80mg UL 100mg
18 mg (5% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 18mg
56 mcg
📊 Market median: 18.0mg (1009 products) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 0.056mg UL 40mg
18 mcg (15% DV)
✅ Within RDA (0.5× RDA of 0.035 mg) 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.018mg
Potassium
12 mg
Proprietary Blend
700 mg

Other Ingredients

Gelatin Lactose Stearic Acid

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS FOR NUTRITIONAL USE: 1-4 capsules up to twice a day for 1-4 months or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

⚠️ Warnings & Precautions

Keep away from Heat, Sunlight and Children.

Consult with health practitioner before taking this product.

Additional Information

Keep away from Heat, Sunlight and Children.

#402 C/10

Provides nutritional support for healthy joints and ligaments.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

Product Details

UPC / SKU 6 35585 04021 1
DSLD Entry Date 2013-06-25
Product Type Other Combinations
Form Capsule
DSLD ID 22128
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
View all evidence for Riboflavin →

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