🟢 89/100

This product is generally safe

  • Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

36 mg (2769% DV)
📊 27.7× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 36mg
250 mg (1563% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 7.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 250mg UL 35mg
50 mg (2941% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
665 mcg DFE (166% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 665mg UL 1.0mg
200 mcg (8333% DV)
📊 83.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.2mg
50 mg (12% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 50mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 100mg

Other Ingredients

Microcrystalline Cellulose Cellulose Stearic Acid Silica Croscarmellose Sodium Coating

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take on tablet twice daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: If pregnant, nursing, or taking medication, consult your healthcare practitioner before use.

Keep out of the reach of children.

🧪 Formulation Notes

EZ Flex features high potency B vitamins as well as magnesium, and the herb turmeric in a formula designed to nutritionally support muscle tissue health.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Nutritonal support for muscle health

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GF Certified Gluten-free

Practitioner exclusive

Product Details

UPC / SKU 7 55571 01595 2
DSLD Entry Date 2020-03-24
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand Metagenics
DSLD ID 216348
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
View all evidence for Riboflavin →

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