St. John's Wort with Folate and B12

product on market Tablet or Pill Metagenics 🟢 Safety: 87/100
Brand: Metagenics
🟢 87/100

This product is generally safe

  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

665 mcg DFE (166% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 665mg UL 1.0mg
250 mcg (10417% DV)
📊 104.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.25mg
450 mg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 450mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Silica Stearic Acid Coating

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (2% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Use as directed by your healthcare practitioner. Recommend to take on an empty stomach.

⚠️ Warnings & Precautions

Warning: Do not use if pregnant or nursing.

Do not use before surgery.

Caution: If taking medication-including blood thinning medication or any medication related to mood modulation-consult your healthcare practitioner before use.

Avoid excessive exposure to UV irradiation (e.g., sunlight; tanning) when using this product.

Keep out of the reach of children.

🧪 Formulation Notes

St. John's Wort with Folate and B12 features a premium extract of St. John's wort, standardized to 0.3% hypericins, which has been shown to support a calm, positive mood. The formula also supplies targeted B vitamins that support a healthy mental state.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Mood support formula

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GF Certified Gluten-free

Practitioner exclusive

Product Details

UPC / SKU 7 55571 91594 8
DSLD Entry Date 2020-03-24
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand Metagenics
DSLD ID 216246
Data Updated 2026-04-11

Research Evidence

43 Research Sources
48 Avg Quality Score
16 Meta Analysis
14 Systematic Review
7 Rct
4 Regulatory Source
1 Clinical Trial
1 Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008
PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017
PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016
PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000
PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025
PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005
PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005
PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019
PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999
PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016
PubMed DOI
View all evidence for St Johns Wort →

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