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St. John's Wort with Folate and B12

product on market Tablet or Pill Metagenics Safety: 87/100
87/100

This product is generally safe

  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort has moderate evidence for supporting mood balance, while folate and vitamin B12 are essential for neurological function and homocysteine regulation. Research generally supports these ingredients for cognitive and emotional health. The profile maintains a high safety score, though St. John's Wort is known to interact with various medications.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for St. John's Wort with Folate and B12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Botanical with Nutrients
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

665 mcg DFE (166% DV)
Exceeds UL by 665.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
250 mcg (10417% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Silica Stearic Acid Coating
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Use as directed by your healthcare practitioner. Recommend to take on an empty stomach.

Warnings & Precautions

Warning: Do not use if pregnant or nursing.

Do not use before surgery.

Caution: If taking medication-including blood thinning medication or any medication related to mood modulation-consult your healthcare practitioner before use.

Avoid excessive exposure to UV irradiation (e.g., sunlight; tanning) when using this product.

Keep out of the reach of children.

Formulation Notes

St. John's Wort with Folate and B12 features a premium extract of St. John's wort, standardized to 0.3% hypericins, which has been shown to support a calm, positive mood. The formula also supplies targeted B vitamins that support a healthy mental state.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Mood support formula

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GF Certified Gluten-free

Practitioner exclusive

Metadata

Product Details

UPC / SKU7 55571 91594 8
DSLD Entry Date2020-03-24
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandMetagenics
DSLD ID216246
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.