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Appetrex Control

product on market Tablet or Pill GNC Total Lean Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 54% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This product contains a blend of B vitamins and calcium, which support cellular energy metabolism and bone health. Research providing evidence for these nutrients is strong, though the specific combination's efficacy for weight control is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Appetrex Control
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
54%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.5 mg (125% DV)
1.2× RDA — within safe limits 76 studies (A:0, B:33)
1.7 mg (131% DV)
1.3× RDA — within safe limits 13 studies (A:0, B:1)
20 mg (125% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
Calcium
141 mg (11% DV)
120 mcg (343% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
Appetrex Herbal Blend
522.5 mg
Yerba Mate leaves extract
500 mg
Grape skin and seed extract
210 mg
Chrysin
200 mg
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Dill Weed extract
5 mg

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Maltodextrin Croscarmellose Sodium Crospovidone Stearic Acid Hydroxypropyl Methylcellulose Calcium Silicate Magnesium Stearate Polyethylene Glycol Polysorbate 80 Vegetable Acetoglycerides Caramel color Ethyl Vanillin Titanium Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take two tablets once daily with water 30-60 minutes before lunch or dinner. Do not take near bedtime.

Warnings & Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. Niacin may cause a temporary flushing reaction.

Formulation Notes

An appetite for success. You're committed to looking and feeling your best, but sometimes you need a little help. Appetrex Control provides clinically studied results you can count on: Shown to reduce calorie intake Fuels energy & metabolism Enhances mental focus

Clinically shown to reduce caloric intake Fuels energy & metabolism

This product contains EGCG from green tea.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No preservatives, sodium free, no wheat, gluten free, no soy, no dairy.

Additional Information

Now that's something you can sink your teeth into! For best results, combine with a diet and exercise plan, like the one at www.totallean.com. Please recycle this box. GNC Total Lean - a simple plan for living leaner: Meal replacements & meal and exercise plan Energy & metabolism support Cleansing & detox Vitamins & on the go snacks For your customized Total Lean experience, visit www.totallean.com In a clinical study of 30 healthy adults (who took Appretrex Control one week followed by a placebo one week apart, or vice versa), calorie intake was reduced by nearly 10% when the subjects took Appetrex Control versus the placebo prior to their first meal at the start of their diet.

Store in a cool, dry place.

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

Clinically Studied

Contributes to a total of 180 mg of caffeine.

Metadata

Product Details

DSLD Entry Date2020-02-26
Product TypeOther Combinations
FormTablet or Pill
BrandGNC Total Lean
DSLD ID213567
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.