🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 54% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size
30 Servings
Other Combinations Product Type
54% Evidence Coverage

Supplement Facts — Evidence Check

1.5 mg (125% DV)
✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 1.5mg
1.7 mg (131% DV)
✅ 1.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1.7mg
20 mg (125% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
2 mg (118% DV)
✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 2mg UL 100mg
Calcium
141 mg (11% DV)
120 mcg (343% DV)
📊 3.4× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.12mg
Appetrex Herbal Blend
522.5 mg
Yerba Mate leaves extract
500 mg
Grape skin and seed extract
210 mg
Chrysin
200 mg
📊 Market median: 250.0mg (337 products) 📚 125 studies (Tier A: 1, B: 41)
This product: 200mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 125mg
Dill Weed extract
5 mg

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Maltodextrin Croscarmellose Sodium Crospovidone Stearic Acid Hydroxypropyl Methylcellulose Calcium Silicate Magnesium Stearate Polyethylene Glycol Polysorbate 80 Vegetable Acetoglycerides Caramel color Ethyl Vanillin Titanium Dioxide

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take two tablets once daily with water 30-60 minutes before lunch or dinner. Do not take near bedtime.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. Niacin may cause a temporary flushing reaction.

🧪 Formulation Notes

An appetite for success. You're committed to looking and feeling your best, but sometimes you need a little help. Appetrex Control provides clinically studied results you can count on: Shown to reduce calorie intake Fuels energy & metabolism Enhances mental focus

Clinically shown to reduce caloric intake Fuels energy & metabolism

This product contains EGCG from green tea.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No preservatives, sodium free, no wheat, gluten free, no soy, no dairy.

Additional Information

Now that's something you can sink your teeth into! For best results, combine with a diet and exercise plan, like the one at www.totallean.com. Please recycle this box. GNC Total Lean - a simple plan for living leaner: Meal replacements & meal and exercise plan Energy & metabolism support Cleansing & detox Vitamins & on the go snacks For your customized Total Lean experience, visit www.totallean.com In a clinical study of 30 healthy adults (who took Appretrex Control one week followed by a placebo one week apart, or vice versa), calorie intake was reduced by nearly 10% when the subjects took Appetrex Control versus the placebo prior to their first meal at the start of their diet.

Store in a cool, dry place.

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

Clinically Studied

Contributes to a total of 180 mg of caffeine.

Product Details

DSLD Entry Date 2020-02-26
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 213567
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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