100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 50% of ingredients have research evidence
A
Label Compliance Grade
What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
Choline bitartrate supports cognitive function and liver health, while betaine HCl is used to increase stomach acid for improved protein digestion. There is moderate evidence for these ingredients in supporting metabolic and digestive health. The overall evidence coverage for this specific formulation is limited.
AI-generated summary based on research evidence. Not medical advice.
Details
Label Data
2 Capsule(s)
Serving Size
Other Combinations
Product Type
Ingredients
Supplement Facts — Evidence Check
Market median: 496.0mg (192 products)
20 studies — no high-quality reviews
1.8× RDA — within safe limits
38 studies (A:1, B:7)
Other Ingredients
Hydroxypropyl Methylcellulose
Stearic Acid
Silica
Magnesium Stearate
Claims
Label Claims — Verification
Unverified
Nutrient
Unverified
All Other
Unverified
Structure/Function
Info
Product Information
Directions for Use
Directions: Adults, take 2 capsules in the morning with breakfast and 2 capsules with dinner, with 8 ounces of water. Take as dietary supplement or as directed by your doctor.
Warnings & Precautions
Warning: Consult your physician prior to use if you are pregnant, nursing, have a medical condition or are taking medications.
Not intended for children.
Keep out of the reach of children.
Do not use if clear safety seal around bottle neck is broken or missing.
Formulation Notes
Choline Bitartrate allows the body to manufacture the neurotransmitter acetylcholine, which assists in bladder, kidney, pancreatic, testicular, and liver functions. It also aids in hormone production and has been shown to help boost the libido. Roex has added Betaine HCl to help increase the secretion of HCl from the stomach's parietal cells, which is critical for proper digestion of proteins and the emulsification of fats.
Essential for healthy brain, memory and nerve function
Supports healthy bladder and kidney function
Contains Betaine HCl for proper digestion and breakdown of proteins and fats
Additional Information
Store at room temperature, in a dry place.
Metadata
Product Details
UPC / SKU0 45245 37120 1
DSLD Entry Date2020-01-25
Product TypeOther Combinations
FormCapsule
Data Updated2026-04-11
Research
Research Evidence
B
Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis
Biological psychiatry. Cognitive neuroscience and neuroimaging
2024
PubMed
DOI
B
Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors.
Guideline
Briefings in bioinformatics
2026
PubMed
DOI
B
Evidence-based clinical practice guidelines for functional dyspepsia 2021.
Guideline
Journal of gastroenterology
2022
PubMed
DOI
B
Scientific Opinion on health claims related to choline
Regulatory Source
EFSA Journal
2011
DOI
C
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials
Meta Analysis
Nutrition reviews
2022
PubMed
DOI
C
Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Nutrient-based therapies for bipolar disorder: a systematic review
Systematic Review
Psychotherapy and psychosomatics
2013
PubMed
DOI
C
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people
Rct
The British journal of nutrition
2007
PubMed
C
Differential metabolism of choline supplements in adult volunteers.
View all evidence for Choline →
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.
