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Brilliant Brain

product on market Tablet or Pill 21st Century Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 71% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines Cognizin Citicoline, L-Theanine, and Caffeine, which have moderate to strong evidence for supporting cognitive focus and alertness. Ginkgo biloba is included for potential neuroprotective effects, though evidence for its efficacy varies. Overall, the ingredient profile is supported by research focused on cognitive enhancement and mental clarity.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Brilliant Brain
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
71%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
130 mg (10% DV)
Within RDA (0.5× RDA) 38 studies (A:1, B:7)
100 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
50 mg
Market median: 180.0mg (239 products) 49 studies (A:1, B:19)
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
Bioperine
5 mg

Other Ingredients

Cellulose Croscarmellose Sodium Stearic Acid Silicon Dioxide Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, adults take two (2) tablets daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage.

For best results, take daily.

Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition, including neurologic, neuromuscular, psychiatric or movement disorders, or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

This product contains caffeine. Avoid additional consumption of caffeine, which may cause adverse effects.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Formulation Notes

This product contains caffeine.

Cognitive Health & Focus Support 21st Century Brilliant Brain is formulated with Cognizin Citicoline plus Ginkgo Biloba and Turmeric Extract to help support the normal functions of cognitive health and focus support.

With Cognizin Plus Ginkgo Biloba & Turmeric Extract

Gluten free

No added Sugar, Yeast, Preservatives or Artificial Flavors.

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Focused results

Gluten free

Get focused results Cognitive health support Overall focus support Brain function support

91652-501481-0219N

Metadata

Product Details

UPC / SKU7 40985 27933 5
DSLD Entry Date2019-08-23
Product TypeOther Combinations
FormTablet or Pill
Brand21st Century
DSLD ID205530
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.