🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 56% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

7.1 Gram(s) Serving Size
24 Servings
Other Combinations Product Type
56% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
5 Gram(s) (2% DV)
0.15 mg (10% DV)
✅ Within RDA (0.1× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 0.15mg
0.17 mg (10% DV)
✅ Within RDA (0.1× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 0.17mg
20 mg (100% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
0.2 mg (10% DV)
✅ Within RDA (0.2× RDA of 1.3 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 0.2mg UL 100mg
0.6 mcg (10% DV)
✅ Within RDA (0.2× RDA of 0.0024 mg) 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.0006mg
Concentrated Calorie Burning Blend: (Combination)
High Energy Mind/Body Matrix: (Herb/Botanical)

Other Ingredients

Gum Arabic Natural flavor Silica Sucralose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Sugar Free

Product Information

📋 Directions for Use

Add to your favorite shake!

Add directly to your favorite shake

Directions: As a dietary supplement, mix one ultra-concentrated scoop (7.1 g) directly into at least 10-12 fl. oz. of your favorite protein shake, meal replacement or smoothie for an invigorating energy and metabolic boost that won't affect the flavor. On training days, take 30-45 minutes prior to exercise. On non-training days, take one serving in the morning. Do not take prior to bedtime. For maximum body-sculpting results, use in conjunction with Total Lean Advanced Tone & Define.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

🧪 Formulation Notes

5g Fiber

No artificial flavors or colors, sugar free

Calories: 10 | Net Carbs: 0g

Fiber: 5g

Sugar: 0g

Each serving provides 200 mg of caffeine.

Additional Information

Store in a cool, dry place.

G4671601

New

Metabolism enhancing powder High energy thermogenic Clinically proven to burn 3X more calories! Fuels metabolism!

Clinically studied

CODE 732228 HPG

For personalized stacking suggestions and to learn more, visit www.GNC.com/TotalLeanAdvanced.

Notice: Significant product settling can occur.

^In a double-blind, randomized, placebo-controlled, cross-over study, 25 subjects exercised on a treadmill on two occasions. On one occasion, the subjects took the thermogenic blend before exercise and on the second occasion, they took a placebo. When the subjects took the thermogenic blend, they burned three times more calories before, 3% more calories during and 12 times more calories after exercise compared to when they took the placebo.

Product Details

UPC / SKU 0 48107 14979 6
DSLD Entry Date 2018-02-23
Product Type Other Combinations
Form Powder
DSLD ID 82700
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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