🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Caplet(s) Serving Size
30 Servings
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

Sodium
130 mg (5% DV)
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)
This product: 1200mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 105mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 100mg
MSM
50 mg
📊 Market median: 1000.0mg (2 products)
This product: 50mg

Other Ingredients

Cellulose Crospovidone Magnesium Stearate Titanium Dioxide Silica Polyethylene Glycol Talc

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

For a complete joint health solution, add TriFlex Joint, Bone & Muscle to your regimen.

Directions: As a dietary supplement, take two caplets twice daily, preferably with meals.

⚠️ Warnings & Precautions

Keep out of reach of children

Contains: Crustaceans (Shrimp).

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

🧪 Formulation Notes

ApresFlex - Features ApresFlex, a potent boswellia serrata extract, which is clinically proven to support a 7 times greater improvement in joint comfort, as well as joint stiffness and function, in as few as 5 days.

Glucosamine/Chondoitin - Provides 1500 mg of glucosamine and 1200 mg of chondroitin, clinical-strength doses for daily, long-term use to support joint health. And more - Also includes MSM, which is an important component for joint cartilage, and turmeric.

Clinical-strength doses of glucosamin/chondroitin & boswellia - plus turmeric

Contains: Crustaceans (Shrimp).

No sugar, no starch, no artificial colors, no artificial flavors, no preservatives, no wheat, gluten free, no corn, no soy, no dairy, yeast free.

Additional Information

In a 30 day, randomized, double-blind, placebo-controlled study of 67 adults, subjects taking 50 mg/day of ApresFlex twice daily experienced a statistically significant difference in mean improvements from baseline for joint comfort, stiffness and function as measured by WOMAC that was 7, 5 and 43 times greater in the ApresFlex group than placebo, respectively, after 30 days. Statistically significant improvements were seen as early as 5 days.

Store in a cool, dry place.

Actual size Our quality commitment to you Since 1935. our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you. Please recycle this box.

It works by targeting pathways related to your body's natural anti-inflammatory response.

New Promotes joint health Improves joint comfort & stiffness in a few as 5 days

Soothes achy joints, promotes mobility & flexibility

CODE 303811 KQG

Gf Gluten free

Conforms to USP <2091> for weight.

Product Details

DSLD Entry Date 2017-09-21
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand GNC
DSLD ID 78621
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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