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SAMe 400 mg

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for SAMe 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
10
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

Cellulose Cellulose Gum Methacrylate Polymer Magnesium Stearate Stearic Acid Silica Citric Acid Ascorbic Acid Triethyl Citrate Colored with Riboflavin and Titanium Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 tablets, one time daily, with a meal.

Warnings & Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs or any prescription antidepressant. Do not use this product if you have bipolar disorder (manic depression) or are pregnant or lactating.

Keep out of reach of children.

Formulation Notes

No milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, soybeans, yeast, corn, glutens, artificial flavors, added sugar, starch or preservatives

SAMe 400 mg per serving

100% vegetarian

Additional Information

ITEM: 16141 F: 3000008 B: 2007417-15064

Helps support mood SAMe helps support healthy liver function Promotes joint health

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 47469 16141 5
DSLD Entry Date2018-01-25
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandNatrol
DSLD ID78176
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.