SAMe 400 mg by Natrol — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Tablet(s) Serving Size

10 Servings

Non-Nutrient/Non-Botanical Product Type

0% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosyl-Methionine

400 mg

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews

This product: 400mg

Other Ingredients

Cellulose Cellulose Gum Methacrylate Polymer Magnesium Stearate Stearic Acid Silica Citric Acid Ascorbic Acid Triethyl Citrate Colored with Riboflavin and Titanium Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take 2 tablets, one time daily, with a meal.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs or any prescription antidepressant. Do not use this product if you have bipolar disorder (manic depression) or are pregnant or lactating.

Keep out of reach of children.

🧪 Formulation Notes

No milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, soybeans, yeast, corn, glutens, artificial flavors, added sugar, starch or preservatives

SAMe 400 mg per serving

100% vegetarian

Additional Information

ITEM: 16141 F: 3000008 B: 2007417-15064

Helps support mood SAMe helps support healthy liver function Promotes joint health

Store in a cool, dry place.

Product Details

UPC / SKU 0 47469 16141 5

DSLD Entry Date 2018-01-25

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Natrol

DSLD ID 78176

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis