SAMe 400 mg
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 100% of ingredients have research evidence
What the Evidence Says
AI-generated · Qwen 3.6 · grounded in 1 source · methodologySAMe is used to support mood and joint health, with moderate evidence suggesting efficacy for depressive symptoms. Research indicates it may assist in maintaining healthy joint function. The current evidence base for these applications is considered limited to moderate.
AI-generated summary based on research evidence. Not medical advice.
Product Label
Label Data
Supplement Facts — Evidence Check
Other Ingredients
Label Claims — Verification
Product Information
Directions for Use
Suggested Use: 1 tablet 1 to 3 times daily. Take tablets on an empty stomach.
Warnings & Precautions
Warning: If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product.
Use this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Formulation Notes
Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine.
Suitable for vegetarians.
Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, preservatives, or artificial flavor or fragrance.
S-adenosyl-L-methionine
Additional Information
These tablets are enteric coated and blister packed for consistent quality and optimal bioactivity. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. A number of clinical studies have demonstrated that SAMe supplementation supports joint comfort, function and mobility in the spine, hips and knees. Preliminary research suggests that SAMe may work by supporting the production of proteoglycans, which are important components of cartilage. Numerous clinical studies have also demonstrated that SAMe can help support a positive outlook. It is able to cross the blood-brain barrier, where it is thought to affect the synthesis of neurotransmitters, and to help maintain normal membrane fluidity. SAMe works together with the B-vitamins, in particular folic acid, making it important to obtain adequate amounts of the B-vitamin complex from diet and supplements. SAMe plays a key role in transmethylation, a vital type of chemical reaction that affects the synthesis, activation, and metabolism of various biological molecules. Compounds that require this reaction include phospholipids, which are fundamental for all cell membrane functions and for cell to cell communication.
SN1400 REV K163
Supports joint comfort, function and mobility
Double strength
Product Details
Research Evidence
Similar Products
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.