Optimized Resveratrol with Nicotinamide Riboside by Life Extension — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
67% of ingredients have research evidence

A Label Compliance Grade

Product Label

Label for Optimized Resveratrol with Nicotinamide Riboside

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Label Data

1 Vegetarian Capsule(s) Serving Size

Other Combinations Product Type

67% Evidence Coverage

Supplement Facts — Evidence Check

Trans-Resveratrol

250 mg

📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)

This product: 250mg

Quercetin

150 mg

📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)

This product: 150mg

NIAGEN Nicotinamide Riboside

100 mg

📊 Market median: 300.0mg (26 products) 📚 7 studies (Tier A: 0, B: 1)

This product: 100mg

Red Grape (fruit) and Wild Blueberry (fruit) blend

40 mg

Fisetin

10 mg

Trans-Pterostilbene

0.5 mg

📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)

This product: 0.5mg

Other Ingredients

Vegetable Cellulose Microcrystalline Cellulose Silica Vegetable Stearate Maltodextrin

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (90% of products) Nutrient (28% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

CAUTION: If you are taking anti-coagulant or anti-platelet medications, or have bleeding disorder, consult your healthcare provider before taking this product.

WARNINGS: -Keep out of reach of children.

-Do not exceed recommended dose. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

🧪 Formulation Notes

Non-GMO

Additional Information

Scan for product info

Q02031A

Advanced Defense Against Cellular Aging*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Store tightly closed in a cool, dry place.

Product Details

UPC / SKU 7 37870 20313 1

DSLD Entry Date 2016-06-24

Product Type Other Combinations

Form Capsule

Brand Life Extension

DSLD ID 60754

Data Updated 2026-04-11

Research Evidence

10 Research Sources

49 Avg Quality Score

8 Rct

1 Systematic Review

1 Clinical Trial

B Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Rct Nature communications 2018

PubMed DOI

C The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials

Systematic Review Frontiers in nutrition 2023

PubMed DOI

C Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.

Rct Nature aging

PubMed DOI

C Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Rct Scientific reports 2019

PubMed DOI

C Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Rct Cell reports 2019

PubMed DOI

C Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin

Rct Aging cell 2023

PubMed DOI

C Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

Rct BMC nephrology 2020

PubMed DOI

C Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19

Clinical Trial ClinicalTrials.gov 2021

ClinicalTrials.gov

C A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.

Rct JCI insight

PubMed DOI

C Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.

Rct Aging cell

PubMed DOI

View all evidence for Nicotinamide Riboside →