SAMe 400 mg by Life Extension — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

Non-Nutrient/Non-Botanical Product Type

0% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosyl-Methionine

400 mg

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews

This product: 400mg

Other Ingredients

Cellulose Mannitol Hydroxypropyl Methylcellulose Phthalate Citric Acid Silica Stearic Acid Glyceryl Triacetate Sodium Starch Glycolate Croscarmellose Sodium Titanium Dioxide yellow Ochre

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS: Take one (1) tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

⚠️ Warnings & Precautions

~ DO NOT EXCEED RECOMMENDED DOSE. ~ Do not purchase if outer seal is broken or damaged.

~ When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

CAUTION: SAMe should not be taken by those diagnosed with bipolar disorder.

WARNINGS ~ KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

S-Adenosyl-Methionine

Additional Information

Store in a cool dry place.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Supports Healthy Bones, Joints, and Emotional Well-Being*

Q00557D

Product Details

UPC / SKU 7 37870 55702 9

DSLD Entry Date 2016-04-22

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Life Extension

DSLD ID 58849

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis