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Energy Enhancer N.O.

product on market Tablet or Pill GNC Pro Performance AMP Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

L-arginine and grape seed extract are used to support nitric oxide production and blood flow, though evidence for performance enhancement is generally limited. Niacin supports cellular energy metabolism. Overall, the evidence coverage for this specific ingredient profile is very low.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Energy Enhancer N.O.
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Tablet(s)
Serving Size
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (50% DV)
Within RDA (0.7× RDA) 196 studies (A:5, B:63)
Market median: 500.0mg (143 products)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
PEG
150 mg

Other Ingredients

Calcium Carbonate Enteric Coating Titanium Dioxide Vegetable Acetoglycerides Sodium Copper Chlorophyllins Sodium Copper Chlorophyllin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: As a dietary supplement, take the contents of one pak 30-60 minutes pre-workout. On non-training days, take the contents of one pak first thing in the morning with food. Do not exceed one pak daily.

Warnings & Precautions

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, allergic or contraindicated to aspirin, or have a medical condition. Discontinue use two weeks prior to surgery, or if upset stomach occurs.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, allergic or contraindicated to aspirin, or have a medical condition. Discontinue use two weeks prior to surgery, or if upset stomach occurs.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

No Wheat, No Gluten, No Dairy, Yeast Free.

Additional Information

In a randomized, double blind, placebo controlled study, 50 healthy untrained male volunteers were given Energy Enhancer N.O. or a placebo. Each subject exercised on a cycle ergometer prior to receiving the supplement or placebo and again after the treatment period was finished. Those subjects supplemented with Energy Enhancer N.O. had a 20% increase in PWCFT (physical working capacity at the fatigue threshold) after four weeks of supplementation relative to the placebo group.

ACTUAL SIZE

Energy Enhancer N.O.

Energy Enhancer N.O. – This advanced nitric oxide product provides 1.5g of micronized arginine and is included to help increase your power output at the onset of fatigue 20%.† It’s clinically studied and designed to enhance blood flow and amplify your intense workouts.* Technologically enhanced for better absorption to maximize muscle performance capacity and give your body the push it needs to go above and beyond your regular workouts.

MegaNatural(R)-BP

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

To maximize total endurance and energy support, use with: • Amplified Endurance Booster – loaded with electrolytes, carbohydrates and BCAA to replenish glycogen stores fast* • Amplified 100% Whey Protein – with fast-absorbing protein to fuel your training*

Clinically Researched^

Store in a cool, dry place.

ADVANCED MUSCLE PERFORMANCE

ADVANCED SPORTS VITAMIN SYSTEM TO AMPLIFY ENDURANCE WITH OVER 50 POWERFUL INGREDIENTS*

CODE 331311 CMG

Daily Endurance Energy Stamina

Each pak contains:

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

Metadata

Product Details

DSLD Entry Date2012-02-23
Product TypeOther Combinations
FormTablet or Pill
DSLD ID5819
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.