🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

3 Tablet(s) Serving Size
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

10 mg (50% DV)
✅ Within RDA (0.7× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 10mg UL 35mg
📊 Market median: 500.0mg (143 products)
This product: 1500mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 300mg
PEG
150 mg

Other Ingredients

Calcium Carbonate Enteric Coating Titanium Dioxide Vegetable Acetoglycerides Sodium Copper Chlorophyllins Sodium Copper Chlorophyllin

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult Male (18-50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS: As a dietary supplement, take the contents of one pak 30-60 minutes pre-workout. On non-training days, take the contents of one pak first thing in the morning with food. Do not exceed one pak daily.

⚠️ Warnings & Precautions

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, allergic or contraindicated to aspirin, or have a medical condition. Discontinue use two weeks prior to surgery, or if upset stomach occurs.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, allergic or contraindicated to aspirin, or have a medical condition. Discontinue use two weeks prior to surgery, or if upset stomach occurs.

KEEP OUT OF REACH OF CHILDREN.

🧪 Formulation Notes

No Wheat, No Gluten, No Dairy, Yeast Free.

Additional Information

In a randomized, double blind, placebo controlled study, 50 healthy untrained male volunteers were given Energy Enhancer N.O. or a placebo. Each subject exercised on a cycle ergometer prior to receiving the supplement or placebo and again after the treatment period was finished. Those subjects supplemented with Energy Enhancer N.O. had a 20% increase in PWCFT (physical working capacity at the fatigue threshold) after four weeks of supplementation relative to the placebo group.

ACTUAL SIZE

Energy Enhancer N.O.

Energy Enhancer N.O. – This advanced nitric oxide product provides 1.5g of micronized arginine and is included to help increase your power output at the onset of fatigue 20%.† It’s clinically studied and designed to enhance blood flow and amplify your intense workouts.* Technologically enhanced for better absorption to maximize muscle performance capacity and give your body the push it needs to go above and beyond your regular workouts.

MegaNatural(R)-BP

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend our quality commitment to you by offering our money-back guarantee.

To maximize total endurance and energy support, use with: • Amplified Endurance Booster – loaded with electrolytes, carbohydrates and BCAA to replenish glycogen stores fast* • Amplified 100% Whey Protein – with fast-absorbing protein to fuel your training*

Clinically Researched^

Store in a cool, dry place.

ADVANCED MUSCLE PERFORMANCE

ADVANCED SPORTS VITAMIN SYSTEM TO AMPLIFY ENDURANCE WITH OVER 50 POWERFUL INGREDIENTS*

CODE 331311 CMG

Daily Endurance Energy Stamina

Each pak contains:

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

Product Details

DSLD Entry Date 2012-02-23
Product Type Other Combinations
Form Tablet or Pill
Bundle Mega Men Powered Endurance Vitapak Program
DSLD ID 5819
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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