🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Label Data

2 Tablet(s) Serving Size
15 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg

Other Ingredients

S-Adenosyl-Methionine Tosylate Disulfate Cellulose Mannitol Citric Acid Stearic Acid Silica Sodium Starch Glycolate modified Cellulose Gum Coating Ingredients

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Kosher Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: Different levels of supplementation may be beneficial for different people. Please refer to our package insert for more information.

⚠️ Warnings & Precautions

Caution: If you suffer from bipolar or manic depression, do not use this product.

If you are currently taking prescription anti-depressants, consult your physician before using SAMe. If you are pregnant or nursing consult your physician before using this product.

Do not use if blister foil is punctured or appears in any way to have been tampered with.

Keep out of reach of children.

🧪 Formulation Notes

S-Adenosyl-Methionine 200mg active SAMe per tablet Each Nutralife SAMe tablet contains 400mg SAMe tosylate disulfate, which includes 200mg of the active ingredient SAMe (S-Adenosyl-Methionine).

Nutralife SAMe enteric coated tablets are Kosher certified by: {Star-K Kosher Certification}

This product contains no peanuts, eggs, dairy, soy, wheat, yeast, gluten, tree nuts, crustacean shellfish, fish or other animal byproducts.

The only time-proven form of SAMe

Additional Information

SAMe is found in every living being. It is an important physiological agent synthesized by the body, and it is involved in over 40 biochemical reactions, some of which effect: Mood SAMe & emotional well-being SAMe is essential to the manufacture of many important brain compounds such as neurotransmitters and phospholipids, which are critical for maintaining healthy mood and emotional well-being.* Joints SAMe & joint mobility Clinical studies indicate that SAMe may plan an important role in the manufacture of cartilage and that SAMe helps produce proteoglycans, essential components in healthy joint function and mobility.* Liver SAMe & liver function SAMe is involved in many processes of the liver. SAMe is essential to maintaining glutathione levels, which is critical for proper liver function.*

As people age, SAMe levels can decrease. SAMe supplementation may be an important factor in maintaining mobility and a healthy body and mind.

nutraLife Health Products Incorporated

Nutralife SAMe is the same form of SAMe that has been available in Europe for over two decades. Nutralife offers the only form of SAMe with 20 years of historical data for both effectiveness and safety. Nutralife SAMe is manufactured and packaged with the highest quality and safety standards.

Nutralife SAMe tablets are sealed in blister packs to ensure product safety, quality, and freshness.

This product should be stored in a cool dry place.

Star-K

Clinically shown to maintain: Mood emotional well-being* Joint health & mobility* Liver function & health*

Blister packed

MANUFACTURED IN ACCORDANCE WITH GMP

Product Details

UPC / SKU 6 86149 18101 7
DSLD Entry Date 2016-02-23
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
Brand Nutralife
DSLD ID 56969
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
View all evidence for Same →

Compare Similar Products

View all Same products →