Osteo Bi-Flex Edge Joint & Energy by Osteo Bi-Flex — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
67% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size

37 Servings

Other Combinations Product Type

67% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 {Calories}

Total Carbohydrates

2 Gram(s) (1% DV)

Thiamine

1.5 mg (100% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.5mg

Riboflavin

1.7 mg (100% DV)

✅ 1.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.7mg

Vitamin B6

2 mg (100% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Vitamin B12

6 mcg (100% DV)

✅ 2.5× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.006mg

Glucosamine HCl

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Joint Shield 5-Loxin Advanced Boswellia serrata extract

100 mg

📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)

This product: 100mg

Joint & Energy Complex

300 mg

Other Ingredients

Cellulose Crospovidone Contains Less Than 2% of

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

2 per day

Directions for adult use: Take two (2) tablets per day preferably with food.

⚠️ Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers.

Keep out of reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Caution: Not intended for use by pregnant or nursing women. If you are taking any medications, including blood thinners, or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

🧪 Formulation Notes

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

Joint Shield plus glucosamine & chondroitin

Free of gluten

Additional Information

Store at room temperature and avoid excessive heat.

Individual results may vary.

New!

Provides energy support Helps strengthen your joints

Are you ready? Every minute of every day, the world asks the same question...Are you ready? Ready for your first step? Your next step? To walk? To run? To ride? To soar? Your joints? They're where motion begins.

To make sure they're always ready to perform. To give you the freedom to chase your joy. So that you can always be...Ready for action

Your mind is always focused and at the top of your game...so make sure you give your body what is needs to keep up.

Joint & Energy helps defend your joints, promote joint mobility, and support energy metabolism, so you can give it everything you've got, every day.

Product Details

DSLD Entry Date 2016-02-23

Product Type Other Combinations

Form Tablet or Pill

Brand Osteo Bi-Flex

DSLD ID 56543

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →