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Brain Factors

product on market Capsule Thorne Safety: 87/100
87/100

This product is generally safe

  • Nicotinamide Riboside Hydrogen Malate: 415mg is 11.9× the Tolerable Upper Intake Level (35mg)
  • 33% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Nicotinamide riboside and betaine are researched for their roles in cellular energy production and methyl donor support, with moderate evidence for metabolic health. CognatiQ is a proprietary blend with more limited public clinical data. The ingredient profile maintains a high safety score, suggesting a low risk of adverse effects for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Nicotinamide Riboside Hydrogen Malate: 415mg is 11.9× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Brain Factors
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Exceeds UL by 11.9× (UL: 35 mg) 196 studies (A:5, B:63)
CognatiQ
100 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hypromellose Calcium Laurate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1 capsule daily or as recommended by your health-care practitioner.

Warnings & Precautions

Tamper evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Formulation Notes

Healthy aging Brain/Nerves

Gluten free

Coffee fruit extract and nicotinamide riboside

Additional Information

Store tightly sealed in a cool, dry place.

T Exclusive

Manufactured in the USA using US & Imported ingredients NSF Contents Certified

Metadata

Product Details

UPC / SKU6 93749 01343 3
DSLD Entry Date2025-08-22
Product TypeOther Combinations
FormCapsule
BrandThorne
DSLD ID336323
Data Updated2026-04-11
Research

Research Evidence

10
Research Sources
49
Avg Quality
8
Rct
1
Systematic Review
1
Clinical Trial
B Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Rct Nature communications 2018 PubMed DOI
C The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials
Systematic Review Frontiers in nutrition 2023 PubMed DOI
C Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.
Rct Nature aging PubMed DOI
C Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Rct Scientific reports 2019 PubMed DOI
C Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Rct Cell reports 2019 PubMed DOI
C Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Rct Aging cell 2023 PubMed DOI
C Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
Rct BMC nephrology 2020 PubMed DOI
C Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19
Clinical Trial ClinicalTrials.gov 2021
C A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.
Rct JCI insight PubMed DOI
C Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.
Rct Aging cell PubMed DOI
View all evidence for Nicotinamide Riboside →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.