🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 46% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2.06 Gram(s) Serving Size
25 Servings
Other Combinations Product Type
46% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
6 mg (353% DV)
📊 4.6× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 6mg UL 100mg
22 mg (5% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 22mg
6 mg (54% DV)
✅ Within RDA (0.5× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 6mg UL 40mg
Potassium
33 mg (1% DV)
Glycine
2900 mg
2400 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 2400mg
Bamboo Leaf Extract
350 mg
200 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 200mg
Gamma-Aminobutyric Acid
75 mg
Magnolia Bark Extract
30 mg

Other Ingredients

Malic Acid Grape Juice, Powder Blue Spirulina Calcium Citrate Mixed Berry, Powder Monk Fruit Extract Thaumatin, Powder Beet Root Juice, Powder

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) No Allergies Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Use only as directed. Mix 2 scoops (1 tsp) with 4 oz water and consume one hour prior to bedtime. Two scoops is the recommended starting dose. If desired results are not observed, use 1 scoop (1/2 tsp). If desired results are still not observed, use 1/2 scoop (1/4 tsp). While 3 scoops may be appropriate for certain individuals, this quantity may have the opposite effect in others. Results vary by individual and are dose-dependent.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

Do not operate machinery or a vehicle or otherwise engage in activities that require you to stay alert. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment for a medical condition.

🧪 Formulation Notes

Sleep Breakthrough is a powerful, melatonin-free, sleep support formula designed to help you fall asleep, stay asleep, and wake up feeling refreshed. Sleep Breakthrough targets several areas involved in sleep, including melatonin and GABA pathways, to calm the body and quiet the mind.

Sleep Breakthrough is a powerful, melatonin-free, sleep support formula designed to help you fall asleep, stay asleep, and wake up feeling refreshed.

Clumping may occur in humid environments.

Manufactured in the USA with domestic and foreign ingredients. Optimized sleep solutions

Blue berry dreams naturally flavored

Get the best sleep ever

Vegan

Gluten free Soy free

Allergens: None.

Additional Information

Packaged by weight not volume. Settling of contents may occur.

Keep tightly capped and store in a cool, dry location.

To reorder or contact us, please visit: BiOptimizers.com.

Product Details

UPC / SKU 0 723098 109751
DSLD Entry Date 2025-06-25
Product Type Other Combinations
Form Powder
Brand BiOptimizers
DSLD ID 334480
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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