SAMe by OmneDiem — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

0% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosylmethionine

400 mg

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews

This product: 400mg

Other Ingredients

Microcrystalline Cellulose Crospovidone Silicon Dioxide, Colloidal Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Take 1-2 tablets per day or as recommended by your healthcare provider.

⚠️ Warnings & Precautions

Storage: Keep closed in a cool, dry place out of reach of children.

Do not use if tamper seal is damaged.

🧪 Formulation Notes

S-Adenosylmethionine

Joint comfort Mood support Liver health

OmneDiem SAMe delivers the highest S,S isomer purity and bioavailability on the market, thanks to our proprietary natural fermentation process. Our enteric-coated tablets feature a natural plant-based coating with absolutely no synthetic copolymers or plasticizers.

Our enteric-coated tablets feature a natural plant-based coating with absolutely no synthetic copolymers or plasticizers.

Tablets are sealed immediately in superior tamper-resistant blister packaging to further ensure optimum stability.

Manufactured in a GMP compliant facility.

Vegetarian Tabs

Does not contain: Sugar, starch, artificial flavors, preservatives, sodium, wheat, gluten, corn, soy, dairy, yeast, lactose, artificial colors, or plasticizers.

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

This package is completely recyclable

Product Details

UPC / SKU 8 50023 77706 5

DSLD Entry Date 2025-07-24

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand OmneDiem

DSLD ID 334398

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis