SAMe 400 mg by Protocol For Life Balance — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

60 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

400 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 400mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Pharmaceutical Glaze Magnesium Stearate Silicon Dioxide Glycerin Sodium Alginate L-Arginine

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested usage: Take 1 tablet 2 to 4 times daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Cautions/Interactions: Theoretically, SAMe could increase the effects and adverse effects of products that increase serotonin levels, including 5-hydroxytryptophan (5- HTP), Hawaiian baby woodrose, L-tryptophan, and St. John's wort. In addition, SAMe may interact with MAO inhibitors, L-Dopa, antidepressants and other serotonergic drugs. Consult healthcare practitioner if pregnant/nursing, taking medication, or have a medical condition, especially bipolar or anxiety disorders.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

How it works: SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient normal aches and pains resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in the maintenance of a positive mood.

Natural color variation may occur in this product.

Supports nervous system and joint health

Stabilized SAMe, smaller tablet

No enteric coating needed

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients.

Additional Information

Refrigeration recommended after opening.

Product Details

UPC / SKU 7 07359 10141 8

DSLD Entry Date 2025-04-24

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Protocol For Life Balance

DSLD ID 326476

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis