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Dual-Tox DPO

product on market Capsule NuMedica Safety: 97/100
97/100

This product looks safe

  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 62% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines B-vitamins (B6, B12, and folate) with botanical extracts to support methylation and detoxification pathways. There is moderate evidence for the role of B-vitamins in homocysteine regulation, while evidence for artichoke and watercress extracts in detoxification is more limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Dual-Tox DPO
Open Full PDF View on NIH DSLD →
Details

Label Data

4 Capsule(s)
Serving Size
15
Servings
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
200 mcg (8333% DV)
83.3× RDA — above typical dose 139 studies (A:1, B:44)
Artichoke Leaf Extract
600 mg
Watercress Aerial Extract
500 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
N-Acetyl-L-Cysteine
200 mg
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Market median: 1000.0mg (2 products)
Market median: 250.0mg (182 products) 10 studies (A:0, B:2)

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose L-Leucine Bamboo Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take four capsules once per day or directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

This formula meets or exceeds cGMP quality standards.

Gluten-Free

Vegetarian

Activated B-Vitamins 5-MTHF

Professional quality formulas Dual phase optimizers to support phase I & II detoxification

Featuring Quatrefolic

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 12527 01532 6
DSLD Entry Date2025-03-25
Product TypeOther Combinations
FormCapsule
BrandNuMedica
DSLD ID323527
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.