🟢 95/100

This product looks safe

  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 57% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
57% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
75 mg (83% DV)
85 mg (5000% DV)
📊 65.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 85mg UL 100mg
680 mcg DFE (170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 680mg UL 1.0mg
750 mg (15000% DV)
📊 150.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 750mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 150mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 75mg
BioPerine
2 mg

Other Ingredients

Hydroxypropyl Methylcellulose Bamboo Silica

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take two capsules 1-2 times per day or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

🧪 Formulation Notes

Corti-B Plex supplies significant amounts of the water-soluble B vitamins, pantothenic acid and Vitamin B6, to support many physiological functions associated with adrenal hormone production and regulation. This formula also works to enhance Coenzyme A production and the body's production of energy. The 5-MTHF in this formula - Quatrefolic - is the most biologically active form of folate, allowing rapid uptake into the bloodstream. The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate. A full spectrum of bioflavonoids have been added for antioxidant protection, and the addition of I-carnitine in the highly bioactive form, acetyl I-carnitine, greatly enhances the activation of the pantothenic acid kinase - the first, and most important, enzyme involved in the metabolic conversion of pantothenic acid to Coenzyme A.

This formula meets or exceeds cGMP Quality Standards.

Rapid Uptake 5-MTHF Bioactive Folate B Activated B-Vitamins

Professional quality formulas Adrenal hormone production support with Bioflavonoids

Corti-B Plex Featuring 5-MTHF as Quatrefolic

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 8 12527 01081 9
DSLD Entry Date 2025-06-25
Product Type Other Combinations
Form Capsule
Brand NuMedica
DSLD ID 323506
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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