🟢 87/100

This product is generally safe

  • Folate: 1665mg is 1665.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1665mg is 1665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
30 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1665 mcg DFE (416% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1665mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 400mg

Other Ingredients

Microcrystalline Cellulose Methacrylic Acid Copolymer Titanium Dioxide Silica Triethyl Citrate Magnesium Stearate Stearic Acid Silica Mannitol Carboxymethylstarch Sodium Salt

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one tablet daily 30 minutes before a meal on an empty stomach with water or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warning: Do not use if pregnant or nursing. Caution: If you have a history of psychiatric disorders or if you are taking medication, particularly antidepressants such as MAO inhibitors or selective serotonin reuptake inhibitors (SSRIs), consult your healthcare practitioner prior to use.

Keep out of the reach of children.

This product is manufactured in a facility that produces products containing wheat, gluten, milk, egg, soy, fish, and crustacean shellfish ingredients.

Practitioner Exclusive

🧪 Formulation Notes

Blisphora features SAMe (s-adenosyl-L-methionine), a compound native to the body that is a component of many biochemical reactions. This formula combines folate (the next generation of folate with improved bioavailability) and vitamin B12 (as easy-to-absorb methylcobalamin) to support SAMe metabolism, methylation, and healthy neurotransmitter synthesis for a balanced mood: Foil-wrapped, enteric-coated tablets ensure product stability.

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

Formulated to support a healthy mood and methylation

Features SAMe, folate, and vitamin B12

Product Details

UPC / SKU 7 55571 93625 7
DSLD Entry Date 2025-02-23
Product Type Other Combinations
Form Tablet or Pill
Brand Metagenics
DSLD ID 323332
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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