🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
15 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg

Other Ingredients

Hydroxypropylmethylcellulose Water Nu-Flow

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use Adults, as a dietary supplement, take one packet with your largest meal of the day.

⚠️ Warnings & Precautions

Consult a medical doctor before taking this or any other nutritional supplement if you are pregnant, nursing, have or suspect a medical condition or are taking any medications.

Keep out of reach of children.

🧪 Formulation Notes

Probiotics, HCL, Enzymes 10 Probiotics billion colony forming units (At the time of manufacture)

Supplement Packets Formulated to help support healthy gut flora & optimal digestion

Betaine HCL Hydrochloric acid is the stomach's innate way to assist with the breakdown of food. In combination with enzymes, our betaine HCl forms a potent 1-2 punch to support normal stomach acid function and to support digestion and nutrient absorption.

Unique formula designed to Break down food & absorb nutrients Support the immune system Help support healthy gut flora Digest Major macronutrients Healthy gut biome A gut biome of friendly probiotic bacteria is not only important for digestion, it is also where a great deal of our important nutrients are produced. In addition, these all-important little allies are also responsible for maintaining a healthy immune system. In order to support the gut biome, we include five acid-resistant strains of probiotics, along with S. boulardii and prebiotic food to feed our little buddies.

Dairy free Soy free Gluten free

Additional Information

Store in a cool, dry place.

#GETONNIT

Product Details

UPC / SKU 8 19444 01441 8
DSLD Entry Date 2025-02-23
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand Onnit
Bundle Total Gut Health
DSLD ID 321557
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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