SAM-e 400 mg by Rite Aid — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

400 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 400mg

Other Ingredients

Dicalcium Phosphate Cellulose Stearic Acid Croscarmellose Magnesium Stearate Silica Cellulose Triacetin Propylene Glycol Methacrylic acid Titanium Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: As a dietary supplement for adults, take one (1) tablet daily. If benefits are not achieved within two weeks, you may require a higher level of supplementation. Gradually increase the number of tablets up to four (4) in divided doses daily (maximum 1,600 mg/day). In order to obtain maximum benefits, SAM-e should be taken on an empty stomach, at least 30 minutes prior to a meal.

⚠️ Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications, including antidepressants, or have any medical condition, including any mental health disorder, consult your doctor before use.

May cause gastrointestinal discomfort. If any adverse reactions occur, immediately stop using the product and consult your doctor. Important: Tamper evident seal under cap. Do not use if seal is broken or missing. Do not eat freshness packet. Keep packet in bottle until all product has been consumed.

Keep out of reach of children.

🧪 Formulation Notes

Gluten free No artificial flavors Soy free Dairy free Wheat free Free from Gluten free No Artificial flavors

Vegan

SAM-e 400mg per tablet

Enteric coated Supports healthy mood and joint health

Satisfaction Guarantee If you're not satisfied, we'll happily refund your money.

Additional Information

Store in a cool, dry place.

Product Details

UPC / SKU 0 11822 28816 3

DSLD Entry Date 2024-11-22

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Rite Aid

DSLD ID 320492

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis