Home/ Supplements/ Niacin/ Heart Essentials Cholest Wise

Heart Essentials Cholest Wise

product on market Softgel Capsule Puritan's Pride Safety: 96/100
96/100

This product looks safe

  • Niacin: 600mg is 17.1× the Tolerable Upper Intake Level (35mg)
  • 40% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The primary active component, a phytosterol complex, has strong evidence for reducing LDL cholesterol by limiting dietary cholesterol absorption. Niacin is also included to support lipid profiles, though its effects vary by dosage. Overall, the ingredient profile is supported by moderate to strong research for cardiovascular health.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 600mg is 17.1× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Heart Essentials Cholest Wise
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Softgel(s)
Serving Size
40
Servings
Other Combinations
Product Type
40%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
20 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Cholesterol
10 mg (3% DV)
600 mg (3750% DV)
Exceeds UL by 17.1× (UL: 35 mg) 196 studies (A:5, B:63)
Phytosterol Complex
975 mg
750 mg
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)
150 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Pantethine
37.5 mg
Policosanol
7.5 mg
Market median: 500.0mg (497 products) 135 studies (A:0, B:40)

Other Ingredients

Gelatin Glycerin Soybean Oil Soy Lecithin Paprika Extract Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Approved Health
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: For adults, take three (3) softgels daily, preferably with a meal.

Warnings & Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, including blood thinners, planning any medical or surgical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Notice: Consult your doctor before taking this product, or if you are switching niacin products. Nicotinic acid may cause a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash. Sensitive individuals may experience unexpected drop of blood pressure or dizziness, especially if you have a history of low blood pressure or use antihypersensitive medication. Do not take more than 3 softgels of this product per day, except under the supervision of a physician.

Contains soy and fish (anchovy, herring, mackerel, sardine) ingredients.

Formulation Notes

Cholest Wise with beneficial Phytosterols

May reduce the risk of heart disease Diets low in saturated fat and cholesterol that include 2 g per day of plant sterols eaten with meals or snacks may reduce the risk of heart disease through the immediate link of blood total and LDL cholesterol. A serving of Cholest Wise supplies 0.6 g of plant sterols. Different color Same product

Contains ingredients that may result in a variation of color and appearance over time.

Additional Information

Store at room temperature.

Quality Assured

To reorder item #17077 www.puritan.com

Metadata

Product Details

UPC / SKU0 25077 17077 7
DSLD Entry Date2024-08-22
Product TypeOther Combinations
FormSoftgel Capsule
BrandPuritan's Pride
DSLD ID318281
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.