Heart Essentials Cholest Wise

product on market Softgel Capsule Puritan's Pride 🟢 Safety: 96/100
Brand: Puritan's Pride
🟢 96/100

This product looks safe

  • Niacin: 600mg is 17.1× the Tolerable Upper Intake Level (35mg)
  • 40% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 600mg is 17.1× the Tolerable Upper Intake Level (35mg)

Label Data

3 Softgel(s) Serving Size
40 Servings
Other Combinations Product Type
40% Evidence Coverage

Supplement Facts — Evidence Check

Calories
20 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Cholesterol
10 mg (3% DV)
600 mg (3750% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 17.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 600mg UL 35mg
Phytosterol Complex
975 mg
750 mg
📊 Market median: 750.0mg (447 products) 📚 388 studies (Tier A: 18, B: 204)
This product: 750mg UL 3000mg
150 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 150mg
Pantethine
37.5 mg
Policosanol
7.5 mg
3.75 mg
📊 Market median: 500.0mg (497 products) 📚 132 studies (Tier A: 0, B: 40)
This product: 3.75mg

Other Ingredients

Gelatin Glycerin Soybean Oil Soy Lecithin Paprika Extract Silica

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Approved Health
❓ Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: For adults, take three (3) softgels daily, preferably with a meal.

⚠️ Warnings & Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, including blood thinners, planning any medical or surgical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Notice: Consult your doctor before taking this product, or if you are switching niacin products. Nicotinic acid may cause a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash. Sensitive individuals may experience unexpected drop of blood pressure or dizziness, especially if you have a history of low blood pressure or use antihypersensitive medication. Do not take more than 3 softgels of this product per day, except under the supervision of a physician.

Contains soy and fish (anchovy, herring, mackerel, sardine) ingredients.

🧪 Formulation Notes

Cholest Wise with beneficial Phytosterols

May reduce the risk of heart disease Diets low in saturated fat and cholesterol that include 2 g per day of plant sterols eaten with meals or snacks may reduce the risk of heart disease through the immediate link of blood total and LDL cholesterol. A serving of Cholest Wise supplies 0.6 g of plant sterols. Different color Same product

Contains ingredients that may result in a variation of color and appearance over time.

Additional Information

Store at room temperature.

Quality Assured

To reorder item #17077 www.puritan.com

Product Details

UPC / SKU 0 25077 17077 7
DSLD Entry Date 2024-08-22
Product Type Other Combinations
Form Softgel Capsule
Brand Puritan's Pride
DSLD ID 318281
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
PubMed DOI
View all evidence for Niacin →

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