🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Softgel(s) Serving Size
Non-Nutrient/Non-Botanical Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 500mg

Other Ingredients

Soybean Oil Gelatin Glycerin Water Soy Lecithin yellow Beeswax Colors added

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested use: Take one softgel daily, with a meal. For easier swallowing, take with water before and during ingestion.

⚠️ Warnings & Precautions

Keep out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: Not intended for pregnant or lactating women.

Consult your doctor before use if you have or have had liver or other medical conditions. Discontinue use and consult your doctor if any adverse reactions occur. Most people should not experience flushing when using this product. However a few sensitive individuals may experience some flushing. Do not take on an empty stomach.

Not for use by persons under age of 18 years.

Contains: Soy.

🧪 Formulation Notes

Flush-free Niacin Inositol Hexanicotinate 500 mg

Nature Made's Flush-free Niacin is an important B vitamin source that helps support general blood vessel and circulatory function. This is a flush-free niacin product which is appropriate for general circulatory function and may not provide the same type of benefits as a regular niacin supplement.

Colors derived form natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Contains: Soy.

Additional Information

List No. 4292 L200 Cat. A561 5A009 ITEM # 1114000

USP Dietary Supplement Verified

Helps support general blood vessel & circulatory function

Keep bottle tightly closed. Store in a cool, dry place.

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org.

Product Details

UPC / SKU 0 31604 04292 9
DSLD Entry Date 2018-09-21
Product Type Non-Nutrient/Non-Botanical
Form Softgel Capsule
Brand Nature Made
DSLD ID 180399
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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