Home/ Supplements/ Niacin/ Flush-free Niacin 500 mg

Flush-free Niacin 500 mg

product on market Softgel Capsule Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Inositol hexanicotinate is a flush-free form of niacin used to support cholesterol levels and cardiovascular health. Research providing evidence for this specific compound is limited compared to nicotinic acid. The ingredient profile is generally considered safe for consumption.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Flush-free Niacin 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Fat
0.5 Gram(s) (1% DV)
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Soybean Oil Gelatin Glycerin Water Soy Lecithin yellow Beeswax Colors added
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take one softgel daily, with a meal. For easier swallowing, take with water before and during ingestion.

Warnings & Precautions

Keep out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: Not intended for pregnant or lactating women.

Consult your doctor before use if you have or have had liver or other medical conditions. Discontinue use and consult your doctor if any adverse reactions occur. Most people should not experience flushing when using this product. However a few sensitive individuals may experience some flushing. Do not take on an empty stomach.

Not for use by persons under age of 18 years.

Contains: Soy.

Formulation Notes

Flush-free Niacin Inositol Hexanicotinate 500 mg

Nature Made's Flush-free Niacin is an important B vitamin source that helps support general blood vessel and circulatory function. This is a flush-free niacin product which is appropriate for general circulatory function and may not provide the same type of benefits as a regular niacin supplement.

Colors derived form natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Contains: Soy.

Additional Information

List No. 4292 L200 Cat. A561 5A009 ITEM # 1114000

USP Dietary Supplement Verified

Helps support general blood vessel & circulatory function

Keep bottle tightly closed. Store in a cool, dry place.

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org.

Metadata

Product Details

UPC / SKU0 31604 04292 9
DSLD Entry Date2018-09-21
Product TypeNon-Nutrient/Non-Botanical
FormSoftgel Capsule
BrandNature Made
DSLD ID180399
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.