Home/ Supplements/ Folate/ 5-MTHF 667 mg DFE with B12

5-MTHF 667 mg DFE with B12

product on market Capsule Kirkman Safety: 80/100
80/100

This product is generally safe

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and vitamin B12 are essential nutrients that support cellular methylation and neurological function. There is strong research evidence supporting their roles in red blood cell formation and homocysteine regulation. This combination is generally well-tolerated for maintaining systemic health.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for 5-MTHF 667 mg DFE with B12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
200
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
6 mcg (250% DV)
2.5× RDA — within safe limits 139 studies (A:1, B:44)

Other Ingredients

Microcrystalline Cellulose Hypromellose Water
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take one capsule daily or as directed by a physician.

Warnings & Precautions

Keep out of reach of children. Formulated for adults and children four years and older. For children under four, consult a physician.

Formulation Notes

Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, and sesame

Hypoallergenic

Gluten-free

Supports the production of new cells and cognitive performance

Additional Information

Important: Store in a cool dry place and tightly capped.

Ultra tested cGMP

Metadata

Product Details

UPC / SKU8 12325 02860 3
DSLD Entry Date2024-09-25
Product TypeVitamin
FormCapsule
BrandKirkman
DSLD ID317686
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.