5-MTHF 667 mg DFE with B12
80/100
This product is generally safe
- Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1 Capsule(s)
Serving Size
200
Servings
Vitamin
Product Type
100%
Evidence Coverage
Supplement Facts — Evidence Check
667 mcg DFE
(167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
6 mcg
(250% DV)
✅ 2.5× RDA — within safe limits
📚 138 studies (Tier A: 1, B: 44)
Other Ingredients
Microcrystalline Cellulose
Hypromellose
Water
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (77% of products)
Nutrient (60% of products)
Approved Health (5% of products)
Target Groups
Children 4 or More Years of Age
Adult (18 - 50 Years)
No Allergies
Gluten Free
Dairy Free
Product Information
📋 Directions for Use
Suggested use: Take one capsule daily or as directed by a physician.
⚠️ Warnings & Precautions
Keep out of reach of children. Formulated for adults and children four years and older. For children under four, consult a physician.
🧪 Formulation Notes
Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, and sesame
Hypoallergenic
Gluten-free
Supports the production of new cells and cognitive performance
Additional Information
Important: Store in a cool dry place and tightly capped.
Ultra tested cGMP
Product Details
Research Evidence
363
Research Sources
57
Avg Quality Score
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A
Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
A
Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
A
The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
A
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A
Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
A
Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
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