🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Veg Capsule(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 1296mg
acid-stable Protease
300 mg

Other Ingredients

Hypromellose Magnesium Stearate Silicon Dioxide Microcrystalline Cellulose

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Kosher Halal Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1-2 capsules at the beginning of each meal. Do not take on an empty stomach.

⚠️ Warnings & Precautions

Do not take on an empty stomach.

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition (especially acid reflux or upper GI ulcers).

Keep out of reach of children.

Not manufactured with yeast, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

NOW Betaine HCl is formulated to support proper digestive conditions in the stomach. Hydrochloric Acid (HCl) is normally produced in the stomach, where it assists protein digestion by activating pepsin, helps to maintain a healthy balance of gut flora, and stimulates the release of intestinal enzymes. Pepsin is a protease produced in the stomach that partially breaks down proteins in foods. HCl production tends to decline with age, so supplementing with HCl and pepsin may help to maintain normal digestive function. This product uses a vegetarian acid-stable protease with activity equivalent to that of animal-derived pepsin.

Digestive support

Non-GMO

Vegetarian formula Vegetarian/Vegan

Triangle K (Kosher)

Made and quality tested in the USA with globally sourced ingredients.

Not manufactured with yeast, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

Natural color variation may occur in this product.

Crescent H Halal

Additional Information

This bottle is made from 100% PCR (post-consumer recycled) resin.

Triangle K (Kosher)

Digestive Family owned since 1968.

Store in a cool, dry place after opening.

GMP Quality Assured Crescent H Halal

Product Details

UPC / SKU 7 33739 02938 6
DSLD Entry Date 2024-12-21
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand NOW
DSLD ID 313588
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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