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SAMe 200 mg

product on market Tablet or Pill Swanson Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-Adenosyl Methionine is supported by moderate evidence for its role in managing depressive symptoms and supporting joint health. Research indicates it may help regulate mood by influencing neurotransmitter levels in the brain. Current data suggests a high safety profile for most users when taken as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Ascorbyl Palmitate Silica Ascorbic Acid Citric Acid Methacrylic Acid Copolymer Hydroxypropylmethylcellulose Hydroxypropyl Cellulose Calcium Carbonate Riboflavin Propylene Glycol
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take two tablets one to four times per day with water.

Warnings & Precautions

Warning: For adults only. Keep out of the reach of children.

Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder.

Do not use if seal is broken.

Formulation Notes

Promotes emotional wellness, healthy mood and neurotransmitter production Supports healthy joint function Precursor to glutathione, a cellular antioxidant believed to be a "master nutrient" for longevity

Enteric coated to enhance stability.

Emotional wellness and joint health

SAMe 200mg per tablet

Additional Information

Swanson.com or call 1-800-437-4148

Science-Backed Quality Since 1969

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 87614 02217 8
DSLD Entry Date2024-07-25
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandSwanson
DSLD ID308741
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.