SAMe 200 mg by Swanson — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosyl Methionine

400 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 400mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Ascorbyl Palmitate Silica Ascorbic Acid Citric Acid Methacrylic Acid Copolymer Hydroxypropylmethylcellulose Hydroxypropyl Cellulose Calcium Carbonate Riboflavin Propylene Glycol

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take two tablets one to four times per day with water.

⚠️ Warnings & Precautions

Warning: For adults only. Keep out of the reach of children.

Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder.

Do not use if seal is broken.

🧪 Formulation Notes

Promotes emotional wellness, healthy mood and neurotransmitter production Supports healthy joint function Precursor to glutathione, a cellular antioxidant believed to be a "master nutrient" for longevity

Enteric coated to enhance stability.

Emotional wellness and joint health

SAMe 200mg per tablet

Additional Information

Swanson.com or call 1-800-437-4148

Science-Backed Quality Since 1969

Store in a cool, dry place.

Product Details

UPC / SKU 0 87614 02217 8

DSLD Entry Date 2024-07-25

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Swanson

DSLD ID 308741

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis