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SAMe 200

product on market Tablet or Pill Jarrow Formulas Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-adenosyl methionine is used to support mood and joint health. Research provides moderate evidence for its efficacy in managing depressive symptoms and osteoarthritis. However, overall evidence coverage for this specific profile remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe 200
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
20
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Mannitol Hypromellose Acetate Succinate Stearic Acid Triethyl Citrate Riboflavin Glyceryl Behenate Magnesium Stearate Silicon Dioxide Sodium Starch Glycolate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Adults take 1 tablet 1-2 times a day on an empty stomach or as directed by your qualified healthcare professional.

Warnings & Precautions

Warning: Do not use if pregnant or nursing. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.

Individuals with Parkinson's disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some persons.

Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal or blister is broken, damaged or missing.

Formulation Notes

Natural SAMe 200 Jarrow Formulas SAMe 200 provides a full 200 mg SAMe (net yield) from 400 mg of SAMe tosylate disulfate. SAMe 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. With more of the biologically active S,S than R,S form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid), SAMe is a chiral molecule consisting of two forms: (S,S) SAMEe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R, S) structure is biologically inactive.

Jarrow Formulas SAMe is made by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe. SAMe Supports: Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It also has been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood. Joint Health SAMe supports the production for healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage. Liver Function SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.

Naturally Derived SAMe 200 S-Adenosyl methionine Active S,S form

Jarrow Formulas SAMe 200 is foil blister-packed to maximize stability and provides 200 mg of S-Adenosyl Methionine derived from 400 mg of SAMe Tosylate Disulfate.

Vegan

200 mg (net yield) SAMe from 400 mg SAMe tosylate disulfate

Supports balanced mood, joint health, and liver function

In foil blister pack

Enteroguard coating

Gluten free

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.

Regular Strength

Additional Information

Store in a cool, dry place.

Mood support

Metadata

Product Details

UPC / SKU7 90011 20014 7
DSLD Entry Date2024-01-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID307729
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.