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SAMe 400 mg

product on market Tablet or Pill California Gold Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for SAMe 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Ascorbyl Palmitate Silicon Dioxide Ascorbic Acid Citric Acid Methacrylic Acid Copolymer Hydroxypropyl Methylcellulose Polyethylene Glycol Triacetin Titanium Dioxide Riboflavin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1 tablet daily with or without food. Best when taken as directed by a qualified healthcare professional.

Warnings & Precautions

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, and cGMP-compliant facility that may process other products that contain these allergens or ingredients.

Warnings: Keep out of reach of children.

Do not use if pregnant or nursing.

Individuals using physician-prescribed medications such as L-dopa or antidepressants (e.g., selective serotonin Re-uptake inhibitors [SSRIs] and MAOI inhibitors) should consult a physician before using SAMe.

Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe. Do not exceed recommended intake. Please consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements. Note: SAMe may cause headaches & gastrointestinal disturbances (e.g., diarrhea, flatulence & nausea) in some individuals. Please discontinue use if you experience any of these issues.

Individually double-foil blister sealed for quality and your protection. Do not use if blister pack material is punctured or missing.

Formulation Notes

SAMe may help support: Joints SAMe may help support joint health & mobility. Liver SAMe May help support healthy methylation enzymatic processes as well as hepatic glutathione levels, an antioxidant which is vital to a healthy liver. Mood SAMe methylation reactions are involved in the synthesis of neurotransmitters such as dopamine, epinephrine, phosphatidylcholine and serotonin, which may support a healthy mood.

S-Adenosyl methionine from ademetionine 1, 4-Butanedisulfonate

Suitable for vegetarians

Formulated without: No gluten No GMOs No soy

Our SAMe is produced in a temperature-controlled (low temperature-low humidity) environment, using a proprietary fermentation process to ensure high (S,S) isomer levels. Our tablets are enteric coated and are double-foil blister sealed ensuring product integrity and protection from light, moisture and oxygen.

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.

Benefits of individually double-foil blister sealed products: Optimal barrier to light, moisture and oxygen Ensures product integrity & protection Tamper resistant and tamper evident Durable

Additional Information

All California Gold Nutrition products come with a 100% gold guarantee. If you are not completely satisfied with your purchase, return the unused portion within 90 days for a full refund.

Store in a cool dry place. Protect from heat, light, and moisture.

Double-Foil Blister Pack: Foil cavity (foil area/tray where tablets are placed) Foil lid (foil layer/backing that seals the tablets in the foil cavity)

Metadata

Product Details

UPC / SKU8 98220 01177 3
DSLD Entry Date2023-12-14
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID299704
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.