🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Ascorbyl Palmitate Silicon Dioxide Ascorbic Acid Citric Acid Methacrylic Acid Copolymer Hydroxypropyl Methylcellulose Polyethylene Glycol Triacetin Titanium Dioxide Riboflavin

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 1 tablet daily with or without food. Best when taken as directed by a qualified healthcare professional.

⚠️ Warnings & Precautions

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, and cGMP-compliant facility that may process other products that contain these allergens or ingredients.

Warnings: Keep out of reach of children.

Do not use if pregnant or nursing.

Individuals using physician-prescribed medications such as L-dopa or antidepressants (e.g., selective serotonin Re-uptake inhibitors [SSRIs] and MAOI inhibitors) should consult a physician before using SAMe.

Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe. Do not exceed recommended intake. Please consult with a physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements. Note: SAMe may cause headaches & gastrointestinal disturbances (e.g., diarrhea, flatulence & nausea) in some individuals. Please discontinue use if you experience any of these issues.

Individually double-foil blister sealed for quality and your protection. Do not use if blister pack material is punctured or missing.

🧪 Formulation Notes

SAMe may help support: Joints SAMe may help support joint health & mobility. Liver SAMe May help support healthy methylation enzymatic processes as well as hepatic glutathione levels, an antioxidant which is vital to a healthy liver. Mood SAMe methylation reactions are involved in the synthesis of neurotransmitters such as dopamine, epinephrine, phosphatidylcholine and serotonin, which may support a healthy mood.

S-Adenosyl methionine from ademetionine 1, 4-Butanedisulfonate

Suitable for vegetarians

Formulated without: No gluten No GMOs No soy

Our SAMe is produced in a temperature-controlled (low temperature-low humidity) environment, using a proprietary fermentation process to ensure high (S,S) isomer levels. Our tablets are enteric coated and are double-foil blister sealed ensuring product integrity and protection from light, moisture and oxygen.

Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.

Benefits of individually double-foil blister sealed products: Optimal barrier to light, moisture and oxygen Ensures product integrity & protection Tamper resistant and tamper evident Durable

Additional Information

All California Gold Nutrition products come with a 100% gold guarantee. If you are not completely satisfied with your purchase, return the unused portion within 90 days for a full refund.

Store in a cool dry place. Protect from heat, light, and moisture.

Double-Foil Blister Pack: Foil cavity (foil area/tray where tablets are placed) Foil lid (foil layer/backing that seals the tablets in the foil cavity)

Product Details

UPC / SKU 8 98220 01177 3
DSLD Entry Date 2023-12-14
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 299704
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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