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B12 Folate

product on market Capsule Pure Encapsulations Safety: 80/100
80/100

This product is generally safe

  • Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and Vitamin B12 are essential nutrients that support red blood cell formation and neurological function. There is strong evidence for their role in maintaining homocysteine levels and supporting cellular methylation. These ingredients are generally well-tolerated when taken within recommended daily allowances.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B12 Folate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1333 mcg DFE (333% DV)
Exceeds UL by 1333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
800 mcg (33333% DV)
333.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Plant Fiber Cellulose Water Ascorbyl Palmitate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.

Warnings & Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Formulation Notes

Certified Gluten-Free by the Gluten-Free Certified Organization, www.gluten.org

B12 Folate with Metafolin L-5-MTHF; Supports red blood cell function, energy metabolism and neurological health

B12 Folate with Metafolin L-5-MTHF; Supports red blood cell function, energy metabolism and neurological health Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Metadata

Product Details

UPC / SKU7 66298 02396 0
DSLD Entry Date2023-11-22
Product TypeVitamin
FormCapsule
DSLD ID299031
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.