🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg

Other Ingredients

S-Adenosyl-Methionine Tosylate Disulfate Cellulose Mannitol Citric Acid Stearic Acid Silica Sodium Starch Glycolate Modified Cellulose Gum Methacrylic Acid Copolymer Hydroxypropyl Methylcellulose Triacetin Titanium Dioxide yellow Ochre

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Kosher Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: Clinical studies show that supplementation of 400 mg (or one tablet) a day is effective for most people. Different levels of supplementation may be beneficial to some people. Please refer to our package insert for more information.

⚠️ Warnings & Precautions

Caution: Do not use if blister foil is punctured or appears in any way to have been tampered with.

Keep out of reach of children.

If you are currently taking prescription anti-depressants, consult your physician before using SAMe. If you are pregnant or lactating, consult your physician before taking this product.

If you suffer from bipolar (manic) depression, do not use this product.

If you are pregnant or lactating, consult your physician before taking this product.

NutraLife SAMe tablets are sealed in blister packs to ensure product safety, quality and freshness.

🧪 Formulation Notes

400 mg active S-Adenosyl-Methionine per tablet

Manufactured in Accordance with GMP

Clinically shown to maintain: Mood & emotional well being Healthy liver function Joint health and comfort Joint mobility

SAMe is found in every living being. It is an important physiological agent synthesized by the body, and it is involved in over 40 biochemical reactions, some of which effect: MOOD SAMe and Emotional Well-Being: SAMe is essential to the manufacture of many important brain compounds such as neurotransmitters and phospholipids, which are critical for maintaining healthy mood and emotional well-being. JOINTS SAMe and Joint Mobility: Clinical Studies indicate that SAMe may play an important role in the manufacture of cartilage and that SAMe helps produce proteoglycans, essential components in healthy joint function and mobility. LIVER SAMe and Liver Function: SAMe is involved in many processes of the liver. SAMe is essential to maintaining glutathione levels, which is critical for proper liver function. As people age, SAMe levels can decrease. SAMe supplementation may be an important factor in maintaining mobility, and a healthy body and mind. NutraLife SAMe: NutraLife SAMe is the same form that has been available in Europe for over two decades. NutraLife offers the only form of SAMe with 20 years of historical data for both effectiveness and safety. NutraLife SAMe is manufactured and packaged with the highest quality and safety standards.

Each NutraLife SAMe tablet contains 400 mg of active S-Adenosl-methionine and is manufactured in full accordance with GMP.

Nutralife SAMe is the original SAMe brand introduced to the United States almost a decade ago. Nutralife SAMe continues to be made with the highest quality active S, S isomer SAMe raw material.

Nutralife SAMe is kosher certified by Star-K and contains NO animal byproducts.

Nutralife SAMe does not contain Talc.

Nutralife SAMe tablets are manufactured in a carefully controlled environment and are cold from blister packed to ensure a more than two year stability rating.

NutraLife SAMe enteric coated tablets are Kosher certified by: Star-K (Kosher)

This product contains no peanuts, eggs, dairy, soy, wheat, yeast, gluten, tree nuts, crustacean shellfish, fish or other animal byproducts.

Each NutraLife SAMe tablet contains 800 mg SAMe tosylate disfulate, which includes 400 mg of the active ingredient SAMe (S-Adenosyl-Methionine).

Additional Information

Value size!

This product should be stored in a dry, cool place.

Star-K (Kosher)

Product Details

DSLD Entry Date 2023-09-25
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
Brand NutraLife
DSLD ID 293168
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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