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Liver Optima

product on market Capsule NutraKey Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 38% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This formula contains milk thistle and N-acetyl cysteine, which have moderate evidence for supporting liver function and antioxidant activity. L-glutathione and grapeseed extract provide additional cellular protection, though overall clinical evidence for this specific combination is limited. The profile maintains a high safety score with no significant concerns noted.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Liver Optima
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
38%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
L-Glutathione
100 mg
Bupleurum Root Concentrate
100 mg
Grapeseed extract
100 mg
Market median: 300.0mg (159 products)
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
Scute Root Concentrate
50 mg
Pueraria Root Concentrate
50 mg
50 mg
Market median: 650.0mg (87 products) 1 studies — no high-quality reviews
30 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
30 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
30 mg
Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

Gelatin Rice Flour
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended use: Take 1 serving (3 capsules) with water or your favorite beverage in the morning or mid-day before lunch. To maximize results, drink at least 64 ounces of water daily while using this product.

Warnings & Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Do not use if seal is broken.

Formulation Notes

Comprehensive liver health and detox formula Liver Optima is a carefully formulated blend of botanical extracts and antioxidants designed to be comprehensive solution for natural liver support and detoxification.

Each of its ingredients contribute unique properties that fortify the body and help support optimum liver health.

Milk thistle has been shown in numerous clinical studies to support healthy liver function. N-acetyl cysteine (NAC) and L-methionine are two amino acids well known for their ability to enhance glutathione production in the liver. Glutathione is a major antioxidant that plays an essential role in liver detoxification.

13 active detoxifying ingredients Promote optimal liver health Protects against free-radicals Stabilize metabolism Antioxidants protect your liver Antioxidants protect healthy cells from harmful free radicals and other toxins that build up in your body. Free radicals are molecules are that can cause damage to healthy cells and make them unstable. Neutralizing free radicals is an important part of detoxification.

Health essentials Ultra pure ingredients

Ultra micronized Max bioavailability Rejuvenating botanical formula Support healthy liver function Detoxification and cleansing 13 active detoxification ingredients

Pharmaceutical grade

High-performance liquid chromatography (HPLC) verified

Additional Information

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Made in the USA

Metadata

Product Details

UPC / SKU4 56355 73413 6
DSLD Entry Date2023-06-22
Product TypeOther Combinations
FormCapsule
DSLD ID287416
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.